Detailed information of TA system TA170293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TacT2-ataR/DUF1778(antitoxin)
• Location: 1974702..1975455
• Replicon: chromosome
• Accession: NZ_CP060396
• Organism: Synechococcus sp. CBW1006

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: H8F26_RS09405
• Protein ID: WP_197153729.1
• Coordinates: 1974970..1975455 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: H8F26_RS09400
• Protein ID: WP_197153728.1
• Coordinates: 1974702..1974983 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F26_RS09390	1971477..1972352	-	876	WP_197153726.1	hypothetical protein	-
H8F26_RS09395	1972541..1974742	+	2202	WP_197153727.1	AAA family ATPase	-
H8F26_RS09400	1974702..1974983	+	282	WP_197153728.1	DUF1778 domain-containing protein	Antitoxin
H8F26_RS09405	1974970..1975455	+	486	WP_197153729.1	GNAT family N-acetyltransferase	Toxin
H8F26_RS09410	1975645..1976781	-	1137	WP_197153730.1	IS5 family transposase	-
H8F26_RS09415	1976864..1977088	+	225	WP_197153731.1	hypothetical protein	-
H8F26_RS09420	1977208..1978014	-	807	WP_197153732.1	hypothetical protein	-
H8F26_RS09425	1978013..1978507	+	495	WP_197153733.1	hypothetical protein	-
H8F26_RS09430	1978576..1979121	+	546	WP_197153734.1	hypothetical protein	-
H8F26_RS09435	1979190..1979420	+	231	WP_197153735.1	hypothetical protein	-
H8F26_RS09440	1979429..1979809	+	381	WP_197153736.1	type II toxin-antitoxin system PemK/MazF family toxin	-
H8F26_RS09445	1979824..1980021	+	198	WP_197153737.1	hypothetical protein	-
H8F26_RS09450	1979999..1980403	-	405	WP_197153738.1	DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1975645..1976781	1136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (45-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-89)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17337.93 Da
• Isoelectric Point: 8.7818

>T170293 WP_197153729.1 NZ_CP060396:1974970-1975455 [Synechococcus sp. CBW1006]
MRPPEPLGPQHQLEGFDCGNTALNRWLQQRALANERQGVSRTVVVCSDEDSNVIAYACLSAGAIVLAEVPGALRRNMPDP
LPVVVLGRLAVDRRHQGQGLGRALVADALRRSLAARRLIGARALLVHAIDEQAAAFYRSLGFRPSPLSASTLMLQLSEPD
G

Nucleotide

• Length: 486 bp

>T170293 NZ_CP077262:2339405-2339508 [Citrobacter pasteurii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10315.54 Da
• Isoelectric Point: 4.3184

>AT170293 WP_197153728.1 NZ_CP060396:1974702-1974983 [Synechococcus sp. CBW1006]
MARDQVLQLRASAEQRQLIDQAAAAEGISRTEFILRSCQERARDVLLDRTLFSLTQEQTTALLADLEDSGAAAQDQASIE
RLLDLPQPWHAPA

Nucleotide

• Length: 282 bp

>AT170293 NZ_CP077262:c2339510-2339303 [Citrobacter pasteurii]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGTCCGCGACTAAAGTGGTCTG
AAAAAAAGGGGGATTGTCACTCGCTGCAATGTAAAAACCGCAAGTTCT