Detailed information of TA system TA170292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1811911..1812512
• Replicon: chromosome
• Accession: NZ_CP060396
• Organism: Synechococcus sp. CBW1006

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: H8F26_RS08665
• Protein ID: WP_197158779.1
• Coordinates: 1811911..1812270 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: H8F26_RS08670
• Protein ID: WP_197158780.1
• Coordinates: 1812267..1812512 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F26_RS08650	1808454..1809624	-	1171	Protein_1700	IS3 family transposase	-
H8F26_RS08655	1809672..1810553	+	882	WP_197158777.1	tyrosine-type recombinase/integrase	-
H8F26_RS08660	1810553..1811611	+	1059	WP_197158778.1	transposase	-
H8F26_RS08665	1811911..1812270	-	360	WP_197158779.1	endoribonuclease MazF	Toxin
H8F26_RS08670	1812267..1812512	-	246	WP_197158780.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
H8F26_RS08675	1812686..1813177	-	492	WP_197158781.1	alpha/beta hydrolase	-
H8F26_RS08680	1813170..1814612	+	1443	WP_197158782.1	IS66 family transposase	-
H8F26_RS08685	1814844..1816055	-	1212	WP_197158927.1	IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1808454..1847573	39119

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (9-108)

Antitoxin

• Antitoxin PemI-like (2-79)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 12788.94 Da
• Isoelectric Point: 9.5975

>T170292 WP_197158779.1 NZ_CP060396:c1812270-1811911 [Synechococcus sp. CBW1006]
MTAAYVPDRGDLVWLEFTPQTGSEQAGRRPALVISPKAYNAKVGLALFCPVTSRVKGYPFEVALPEGSGVVGVVLADQLK
SLDWRARKAKLIERASSDVLAMVTARILPLLVPDNPATL

Nucleotide

• Length: 360 bp

>T170292 NZ_CP077262:1221248-1221655 [Citrobacter pasteurii]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCACAGTGGCTCTCTCTGCTCATTCATGGGCTGGTTGCGGT
ATTCATTTTATTGATGCCCTGGCCATTGAGCTACACTCCATTATGGTTGGTTCTGCTCTCTCTGGTGGTGTTTGATAGCG
TACGCAGTCAGCGTCGCATTAACGCTTGTCAGGGAGATATTAGACTGTTAATGGACGGTCGCCTGCGCTGGCAGGGGCAG
GAGTGGTCTATCGTTTGTACACCCTGGATGATTAAAACGGGCATGATGCTGCGTTTGCGTTCCGATGCGGGAAAACGTCA
GCATTTGTGGCTGGCAGCGGACAGCATGGATGACGCAGAGTGGCGGGATTTGCGGCGGTTAATGCTGCAACAGGCGAAGC
AGGGTTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8416.46 Da
• Isoelectric Point: 4.3611

>AT170292 WP_197158780.1 NZ_CP060396:c1812512-1812267 [Synechococcus sp. CBW1006]
VQTRVQKWGNSLGVRIPRGLAEEVGLGAGSEVSLSAKDGELVVKPSVPARLSLDDLLAEVSEENLHSSIDTGSAVGAEIF
C

Nucleotide

• Length: 246 bp

>AT170292 NZ_CP077262:1221001-1221267 [Citrobacter pasteurii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTCGAACATGAGTATGACAACTTAAGTGACGAAGAAAAACGCATCTTTATCCGTCTGCTGGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGAGCAGCTGGAGCAGATGGTGCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA