Detailed information of TA system TA170291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(antitoxin)
• Location: 886601..887187
• Replicon: chromosome
• Accession: NZ_CP060396
• Organism: Synechococcus sp. CBW1006

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: H8F26_RS04190
• Protein ID: WP_197157705.1
• Coordinates: 886601..886858 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: H8F26_RS04195
• Protein ID: WP_197157707.1
• Coordinates: 886852..887187 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F26_RS04160	882391..883299	+	909	WP_197157696.1	MBL fold metallo-hydrolase	-
H8F26_RS04165	883321..884056	+	736	Protein_820	tyrosine-type recombinase/integrase	-
H8F26_RS04170	885263..885472	+	210	WP_197157698.1	type II toxin-antitoxin system HicB family antitoxin	-
H8F26_RS04175	885475..885702	+	228	WP_197157700.1	type II toxin-antitoxin system HicA family toxin	-
H8F26_RS04180	885857..886147	+	291	WP_197157702.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H8F26_RS04185	886157..886465	+	309	WP_197157703.1	putative addiction module antidote protein	-
H8F26_RS04190	886601..886858	+	258	WP_197157705.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Toxin
H8F26_RS04195	886852..887187	+	336	WP_197157707.1	type II toxin-antitoxin system PemK/MazF family toxin	Antitoxin
H8F26_RS04200	887350..887871	+	522	Protein_827	DUF1254 domain-containing protein	-
H8F26_RS04205	887955..888584	+	630	WP_197154053.1	ISAs1 family transposase	-
H8F26_RS04210	888581..889120	+	540	WP_197158971.1	ISAs1 family transposase	-
H8F26_RS04215	889137..890135	+	999	Protein_830	DUF1254 domain-containing protein	-
H8F26_RS04220	890180..891700	+	1521	WP_197157709.1	DUF1254 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	885714..888006	2292

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• mRNA interferase PemK-like (9-109)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9090.37 Da
• Isoelectric Point: 4.3219

>T170291 WP_197157705.1 NZ_CP060396:886601-886858 [Synechococcus sp. CBW1006]
VLGVVVVRAKLVKIGNSRGIRLAKPLLEVAGLADEVEIEAAPGVLTIRPSAHPRAGWAEAASSLEPEGLLDEMSATQFDD
EEWSW

Nucleotide

• Length: 258 bp

>T170291 NZ_CP077262:c1052259-1051882 [Citrobacter pasteurii]
ATGCAAACACAACCCGTATCCCCGGCACGGGAGGCTTCTCCACGTCTGTCACCCGTGGAGATTTGGCAGCGACTTCTGAG
CCACCTGCTGGATCATCACTACGGTCTGGCGCTAAACGACACGCCGTTTGGCAACGACGACGTGATTCAGGAGCACATTG
ACGCCGGTATTTCCCTGTGTGATGCCGTCAATTTTATCGTCGAAAAATACGATCTGGTACGCACTGACCGTTACGGATCC
AGCACTACAGAGCAGTCACCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGTAAGGCCTGTGGACTGATGACACGTAA
CGGCTACAGAGCGGTGACAGATATCACTACAGGCAAATACAGCAAGATGACCCGATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12352.25 Da
• Isoelectric Point: 9.3545

>AT170291 WP_197157707.1 NZ_CP060396:886852-887187 [Synechococcus sp. CBW1006]
MVTEEHVSRGNIFLVALNPTRGSEIRKTRPCAVVSPDELNAHLRTFIVAPLTTGGHPYPFRVRCRFDGKDGHVVADQLRA
VDRDRLVKRLGSLSETTLNELLSVLQAMFAV

Nucleotide

• Length: 336 bp

>AT170291 NZ_CP077262:c1052667-1052308 [Citrobacter pasteurii]
TTGTTGAATAAAACACTGCCGGCAAATCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTT
CGGTGCACGGCTGGTACAGGAAGGCAACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACG
CGGATTTGCGCCATCTCGACCAAGCGTTTCCGGTACTGCTGAAGCAAATGGAACTGATGCTGGTTTCCGGCGAACTCAGT
CCCCGCCATCAGCACTGCGTCACGCTGTATGCAAAGGGACTGACCTGCGAGGCTGACTCACTCGGATCGCATGGCTATAT
CTATATAGCGATTTATCCGACACCATCAGTAACGTCATAA