Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2914119..2914727 Replicon chromosome
Accession NZ_CP060395
Organism Synechococcus sp. CBW1108

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H8F27_RS15800 Protein ID WP_197149366.1
Coordinates 2914437..2914727 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H8F27_RS15795 Protein ID WP_197149365.1
Coordinates 2914119..2914427 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F27_RS15780 2909855..2912356 - 2502 WP_197149360.1 ligase-associated DNA damage response DEXH box helicase -
H8F27_RS15785 2912588..2912743 + 156 WP_197149362.1 DUF1643 domain-containing protein -
H8F27_RS15790 2913160..2913729 - 570 WP_197149364.1 DUF4334 domain-containing protein -
H8F27_RS15795 2914119..2914427 - 309 WP_197149365.1 putative addiction module antidote protein Antitoxin
H8F27_RS15800 2914437..2914727 - 291 WP_197149366.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H8F27_RS15805 2915034..2916677 - 1644 WP_197149367.1 ATP-dependent DNA ligase -
H8F27_RS15810 2916683..2917432 - 750 WP_197149368.1 phytochelatin synthase family protein -
H8F27_RS15815 2917460..2918458 - 999 WP_197149372.1 ligase-associated DNA damage response exonuclease -
H8F27_RS15820 2918430..2919152 - 723 WP_197149373.1 ligase-associated DNA damage response endonuclease PdeM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10773.23 Da        Isoelectric Point: 9.8121

>T170286 WP_197149366.1 NZ_CP060395:c2914727-2914437 [Synechococcus sp. CBW1108]
MIEIREASAYAAWFTGLRDRTAKARIDIRLRRLSLGNSGDIRSVGEGVSELQIYYGPGYRIYLTRQGDTVVILLSGGDKN
SQDQDIRLAKELARNL

Download         Length: 291 bp

>T170286 NZ_CP077260:c4442285-4441968 [Providencia rettgeri]
TTGACTCAGAAGCCAAGTAATAAGCGAGCTAAGCAACCAAGGCAGGTTGCTTATACACCAACGTTTAAGAAGTCATGGGA
ACGATATAACCGAGCGGGCCGTAGGGATATGAATGCGGCTGTTCTCGTTATGGAAATACTGTTTTCTCAAAAAATAATAC
CAAAAGAATATCTTGACCATGAATTAGAAGGTCATGAATGGCAAGGAGCTAGGGAGCTTCATATTGGTGGTGATTTCTTA
CTGGTTTATCGCTTGTCAGATAAAGGTAATTTAATCACTTTCGTTGATATTGGTTCGCACAGTGAATTATTTGGTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10578.07 Da        Isoelectric Point: 5.0041

>AT170286 WP_197149365.1 NZ_CP060395:c2914427-2914119 [Synechococcus sp. CBW1108]
MTKTTTTIWDPAAHLTTSDDVAAYLEAALQDGDPQLVAAALGDIARAKGMSQVARDAGLGRESLYKSLSPSGNPELATIL
KVISALGLELHVTATDKAKMAV

Download         Length: 309 bp

>AT170286 NZ_CP077260:c4442553-4442266 [Providencia rettgeri]
ATGTCAACACTATTGAAAACAACAGATGTTCGTAGTCGAATTGATGAACAATTAAAAGCGGAAGCCACGAGTGTATTACA
AGATTGTGGTTTGACTATTAGCGCAGCTATTCGTTTGTTTTTAGAACAAGTAGTTCAAGAGCAAAGAGTTCCCTTTGAAA
TCAAACGTAAGCAACCTTCGCTGAAAACTACACTAGCGTTGAAAGAAGCTAAAGCTATTGAGCAGCACTACGATTCAATT
AACGAAATGATGGTGGAGTTAAGCAAAGTTGACTCAGAAGCCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References