Detailed information of TA system TA170285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2855285..2855933
• Replicon: chromosome
• Accession: NZ_CP060395
• Organism: Synechococcus sp. CBW1108

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H8F27_RS15505
• Protein ID: WP_197153645.1
• Coordinates: 2855508..2855933 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H8F27_RS15500
• Protein ID: WP_197149273.1
• Coordinates: 2855285..2855521 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F27_RS15480	2851274..2851489	+	216	WP_197153643.1	hypothetical protein	-
H8F27_RS15485	2851609..2853232	+	1624	Protein_3042	FAD-dependent oxidoreductase	-
H8F27_RS15490	2853440..2854924	+	1485	WP_197153644.1	NAD(P)/FAD-dependent oxidoreductase	-
H8F27_RS15495	2854895..2855098	-	204	WP_197149271.1	hypothetical protein	-
H8F27_RS15500	2855285..2855521	+	237	WP_197149273.1	DNA-binding protein	Antitoxin
H8F27_RS15505	2855508..2855933	+	426	WP_197153645.1	type II toxin-antitoxin system VapC family toxin	Toxin
H8F27_RS15510	2856155..2856424	+	270	WP_197149275.1	hypothetical protein	-
H8F27_RS15515	2856907..2857518	+	612	WP_197149277.1	substrate-binding domain-containing protein	-
H8F27_RS15520	2857923..2859199	+	1277	Protein_3049	DDE-type integrase/transposase/recombinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2849641..2869217	19576

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15759.99 Da
• Isoelectric Point: 5.6415

>T170285 WP_197153645.1 NZ_CP060395:2855508-2855933 [Synechococcus sp. CBW1108]
MFLIDTNVISEARKGRRADAGVQDFWAAAARDNTPLFLAAVTIGELRHGVELIRNRGDQQQAQLLEQWLAEVLQTYGDRV
LDLDGDAAQIWGRLRVPNPHNAIDKQIAAIALLHDLMVVTRNIDDFAGCRVRLLNPFQPPP

Nucleotide

• Length: 426 bp

>T170285 NZ_CP077260:3172395-3172703 [Providencia rettgeri]
ATGCAATATTGCCTCTATCAAAACCGAGAAGATACGGTCAAATACCCATATTTACTGGATATTCAAAGTAACATTATTGA
TATATTGAATACTCGTTTAGTCATCCCGTTATTCGATAGCAGGCTAGTTAAAAAGCCATTACCTGTACGCTTAAATCCAC
AATTATCAATCAACGGGCAGGTTTTTATTTTAATGACTCACCAAATGGCTTGCGTCCCTCATTCATTATTAGGGAAAGAA
ATCGTTGACTTAAGTAGCCAGCGAGACACCATTAAACACGCAATTGACTTACTGATTGATGGCTTTTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8295.42 Da
• Isoelectric Point: 4.4930

>AT170285 WP_197149273.1 NZ_CP060395:2855285-2855521 [Synechococcus sp. CBW1108]
MPDLLVRGVDDALVQALKKRAGAHGRSQEAELRAILSAALLSPPRCNLAELLAAMPDVGVDADFQRPGDQAGDRDVFD

Nucleotide

• Length: 237 bp

>AT170285 NZ_CP077260:3172168-3172395 [Providencia rettgeri]
ATGAACAGAACAAAAAAAACCGTCAGTGTCACTGTCGCGCCTGAACTCTACGAACAAGCAAGGCGGGCTAAACTTAACTT
ATCAGCAATACTGGCTTGTGCCTTACAAGCTGAATTAAAACGCCTCGAAGCGCAAAAATGGAAAAATGACAATGTCGAAG
GCTTTAATGAGTTAAACAGGATAAATGAAGAATATGGATTACTCTCAGATAAATACAAGGATTTTTAA