Detailed information of TA system TA170284

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2070747..2071330
• Replicon: chromosome
• Accession: NZ_CP060395
• Organism: Synechococcus sp. CBW1108

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H8F27_RS11295
• Protein ID: WP_197148174.1
• Coordinates: 2071076..2071330 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H8F27_RS11290
• Protein ID: WP_197148173.1
• Coordinates: 2070747..2071079 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F27_RS11270	2066753..2067013	-	261	WP_197148171.1	DUF2442 domain-containing protein	-
H8F27_RS11275	2067006..2067239	-	234	WP_197148172.1	DUF4160 domain-containing protein	-
H8F27_RS11280	2067368..2068959	+	1592	Protein_2215	IS3 family transposase	-
H8F27_RS11285	2069022..2070290	-	1269	WP_197153526.1	IS110 family transposase	-
H8F27_RS11290	2070747..2071079	-	333	WP_197148173.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H8F27_RS11295	2071076..2071330	-	255	WP_197148174.1	type II toxin-antitoxin system HicA family toxin	Toxin
H8F27_RS11300	2071519..2073024	+	1506	WP_197148175.1	IS5 family transposase	-
H8F27_RS11305	2073314..2074765	-	1452	WP_197153527.1	Ni/Fe hydrogenase subunit alpha	-
H8F27_RS11310	2074861..2075466	-	606	WP_197148176.1	potassium channel family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2057169..2079106	21937

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.85 Da
• Isoelectric Point: 11.0836

>T170284 WP_197148174.1 NZ_CP060395:c2071330-2071076 [Synechococcus sp. CBW1108]
MKRKRQRTLELIFSRPASGSLPWRDIEALFQELGGNVSERAGSRVAVVLFGEVRVFHRPHPSPDTDKGAVASIRKWFEEH
GVTP

Nucleotide

• Length: 255 bp

>T170284 NZ_CP077260:2611677-2612135 [Providencia rettgeri]
ATGATTTTATATCGATTGGTTAAATCCAATTTTGCGCATGATGCATGGTCGGGCCAAGGAGCTATGCTCTACGGCGGGCG
TTGGAATCATAAAGGGACTCCTGCTGTTTATACTTCAACAAGTATTTCATTAGCGACCCTTGAAATACTCGTTCACATCA
ATCAAGACATACTATTGAGCCAGTTCAGCTTACTATCCATAGATATCAATGATAAGTACGTGATGAAATTGTCGTTAGAT
CACCTTCCGACAGATTGGCAACAAGACCCCGCACCAACCTCCACCATGGATATTGGCACTATATGGCTTAATAACCAAGA
TAGTCTAGCATTATTAATTCCCTCTTGTATTGTTCCCTATGAATACAACGCAATTATTAACCCGTTACATCCGCAATTTC
AAAAAGCTTTACATACCGTTAAACCACTAGATTTTAGTGTTGACCCGCGCTTAGCATAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12493.06 Da
• Isoelectric Point: 4.9506

>AT170284 WP_197148173.1 NZ_CP060395:c2071079-2070747 [Synechococcus sp. CBW1108]
MNLMNVDGYHARIEYDEETNQFRGEILGLSGGADFYGSSPDELRREFKKSLDVFLEVCKEQGIEPRRQFSGKFNLRIPPE
LHEKLAMTAEVQGKSLNTLAQEALQRSVTA

Nucleotide

• Length: 333 bp

>AT170284 NZ_CP077260:2611219-2611680 [Providencia rettgeri]
ATGAGAAACTATATCCCCACAACCCCACTTCAACCGACTGCTTCATCCTTTAAACCACTGTGGCGCCATGTAGGGTTACC
CGCAGAACGTGGTATTGAGTTAACTCATTTCTTGCGTCAAGGCCTATCTGTCTCTGTCTTAGACAATATCCAAGAATGGT
CAGGAATGAGCAAAACTGAATTATTGCGAATATCCGGCATTAATGAGCGCAATATTGCTCGACGTAAAAATGCTGGCCAG
CCCCTTAATGCTGATGAAAGTGAGAGAATTGCTCGTCTAGTGCGGGTATTCGATGCTGCGGTGCGTTTATTTAATGGAGA
TAAGCACGCGGCAAGTGATTGGCTTAACCACCCAGTTAAAGGGTTAGGACATTTACGCCCTATTGAGCTTATTGCGACAG
AAAGCGGAGCCATTGAAGTGATTGATTTGATTGGCCGTATTGAACATGGCGTATTCTCATGA