Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(antitoxin)
Location 2065021..2065607 Replicon chromosome
Accession NZ_CP060395
Organism Synechococcus sp. CBW1108

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H8F27_RS11260 Protein ID WP_197153525.1
Coordinates 2065350..2065607 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H8F27_RS11255 Protein ID WP_197148169.1
Coordinates 2065021..2065356 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F27_RS11225 2060435..2062231 - 1797 WP_197148164.1 adenylate/guanylate cyclase domain-containing protein -
H8F27_RS11230 2062273..2062578 - 306 WP_197148165.1 hypothetical protein -
H8F27_RS11235 2062730..2063473 - 744 WP_197148166.1 carbonic anhydrase -
H8F27_RS11240 2063646..2064080 - 435 WP_197148167.1 hydrogenase maturation protease -
H8F27_RS11245 2064258..2064410 + 153 WP_197148168.1 hypothetical protein -
H8F27_RS11250 2064466..2064837 - 372 Protein_2209 VOC family protein -
H8F27_RS11255 2065021..2065356 - 336 WP_197148169.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
H8F27_RS11260 2065350..2065607 - 258 WP_197153525.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
H8F27_RS11265 2065743..2066588 - 846 WP_197148170.1 GIY-YIG nuclease family protein -
H8F27_RS11270 2066753..2067013 - 261 WP_197148171.1 DUF2442 domain-containing protein -
H8F27_RS11275 2067006..2067239 - 234 WP_197148172.1 DUF4160 domain-containing protein -
H8F27_RS11280 2067368..2068959 + 1592 Protein_2215 IS3 family transposase -
H8F27_RS11285 2069022..2070290 - 1269 WP_197153526.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2057169..2079106 21937


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(9-109)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9147.39 Da        Isoelectric Point: 4.4621

>T170283 WP_197153525.1 NZ_CP060395:c2065607-2065350 [Synechococcus sp. CBW1108]
MQGVAVVRAKLVKIGNSRGIRLAKPLLEVAGLTDEVEIEAAPGVLTIKPSAHPRAGWAEAASSFEAEGLLDEMSATRFDD
EEWSW

Download         Length: 258 bp

>T170283 NZ_CP077260:1641852-1642262 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACCCAACTGTTCTCAACCTGTGTTCATGGGGTCATTGGGAT
GTTTTTACTATTGGCTCCATGGTCCCCTGGTAACTCAATGATATGGTTGCCGCTATTAGTGGTTGTCGTTGCGAGTTGGG
CAAAGAGCCAGAAAAATATCAGTAAAATAAAAGGGGTTGCTGTACTGGTTAATGGCAATAAGGTTCAGTGGAAGAAAAAT
GAATGGAGAATACTGAAAGCACCTTGGCTTACCCGCTATGGTATATTACTGACACTAGAAGCGTTACAAGGTAAACCACA
AAAGCTCCATTTGTGGGTTGCAAAAGACGCATTGTCGGAAGAGAATTGGCGTAATTTAAACCAATTATTGCTGCAATACC
CTGATATTTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12353.25 Da        Isoelectric Point: 8.2930

>AT170283 WP_197148169.1 NZ_CP060395:c2065356-2065021 [Synechococcus sp. CBW1108]
MVTQECVSRGDIYFVALNPTRGSEIRKTRPCVVVSPDELNAHLRTFIVAPLTTGGHPYPFRVRCSFDGKDGHVVADQLRA
VDRERLVRRLGSLSETTLNELLAVLQAMFAV

Download         Length: 336 bp

>AT170283 NZ_CP077260:1641605-1641871 [Providencia rettgeri]
ATGGATATTGAGAATAAAGCGCGAATTCATTGGGCATGCCGCCGTGGTATGCGTGAATTAGATATTTCAATCATGCCGTT
TTTTGAGTATGAATATGATGACCTAACAACTCACGATAAGCAGGTATTTGTCCGTTTATTAGAATGTGCGGACCCTGATT
TATTCAATTGGCTAATGAATCACGGTCGTCCAGATGATGACGAACTTTTTCGTATGATTAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References