Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1550153..1550835 Replicon chromosome
Accession NZ_CP060395
Organism Synechococcus sp. CBW1108

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8F27_RS08335 Protein ID WP_197153103.1
Coordinates 1550434..1550835 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8F27_RS08330 Protein ID WP_197153101.1
Coordinates 1550153..1550422 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F27_RS08305 1545383..1545673 + 291 WP_197153093.1 DUF1778 domain-containing protein -
H8F27_RS08310 1545670..1546191 + 522 WP_197153449.1 GNAT family N-acetyltransferase -
H8F27_RS08315 1546306..1546764 - 459 WP_197153095.1 type II toxin-antitoxin system VapC family toxin -
H8F27_RS08320 1546761..1547009 - 249 WP_197153097.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
H8F27_RS08325 1547141..1549927 - 2787 WP_197153099.1 preprotein translocase subunit SecA -
H8F27_RS08330 1550153..1550422 + 270 WP_197153101.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H8F27_RS08335 1550434..1550835 + 402 WP_197153103.1 type II toxin-antitoxin system VapC family toxin Toxin
H8F27_RS08340 1550825..1551583 - 759 WP_197153105.1 serine O-acetyltransferase -
H8F27_RS08350 1551758..1552744 - 987 WP_197153107.1 GntR family transcriptional regulator -
H8F27_RS08355 1553176..1553745 - 570 WP_197153109.1 translation initiation factor IF-3 -
H8F27_RS08360 1553781..1554707 - 927 WP_197153111.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-126)

Antitoxin

Antitoxin VapB-like

(1-88)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14586.71 Da        Isoelectric Point: 5.1367

>T170281 WP_197153103.1 NZ_CP060395:1550434-1550835 [Synechococcus sp. CBW1108]
MELVIDPSALMALLLQEAEAESLLEVAAEASVVHLSAASRVELGLVSECSRHGIADSEVEQLLFSLGVQVVPFDQHHLHW
ALHGWRHYGKGRHRAGLNLGDCFSYGLAMALDLPLLFKGDDFARTEVKVALSW

Download         Length: 402 bp

>T170281 NZ_CP077260:c64660-63341 [Providencia rettgeri]
ATGGCGACTTTGCATGTATACATGAATGGTTACTTGGTTGGGGATTTGATTCGTTCAAGTACTGGTGCTCACCAATTTAC
TTATAATAGTCACTGGTTGGAAACATCAGGTGCTCGACCTATTTCTTTATCAATGCCACTTAGGCACCAAGAATATCGAG
GAGACGAAGTTTATAATTTTTTTGATAATCTCCTACCGGACAATATTGAGATACGGAATCGAATTGTTAGTCGTTATCAA
GCGGATTCAAATCAACCTTTCGATTTATTATCTAAGATTGGCCAGGATAGTGTGGGGGCTTTACAACTCATTCTAGATGG
GCAAAGAGTCAGTAATATCAGAAAAATTGAATATAAACCCTTATCTAATAAGCAACTAGAAAAAATATTAACAGGGTATA
AAGCGAATGCACCTTTAGGCATGATTGAAGATGAAGATGACTTTAGGATCTCACTTGCGGGCGCTCAAGAGAAAACCGCA
TTACTCTATTTAGATGGGCATTGGTGCTTACCTCAGAATGCGACTCCAACTACCCATATTATTAAACTTCCCATTGGTAA
AATAGAAAGCCATTCTTATTCGATAGATATGTCGGATAGTGTAGAAAATGAGTATTTATGTTTATTGATAGCAAAAGAGT
TTGGCCTAGATGTGCCTCGTAGCTTTATTTTAAATGTAGGTGAAATAAAGGCGTTAGCGGTTGAACGTTTTGACCGTAAA
TATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATTTTTGTCAAACATTGAATATTTCACCAGCAAGAAA
ATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTACTTATTGGGTTCAATAAATGCAGAGAAAGATAGAT
ATCAGTTTATGAAGAGCCAAGTTTTGTTCTGGCTACTTGCAGCGACGGATGGTCATGCTAAAAATTTTTCATTATTTATT
GAACCTGAAGGCCGTTATCAGTTAACACCTTTTTACGATATTTTGTCCATGTATCCTAGTTATGGGGGGAGGGGAATTAA
CCCTAGAGATGCCAAATTGGCTATGGGACTGAAGGGAACAAAGGGGATGAAATACAATATAGAGCAAATTTTCCCAAGAC
ATTTTTTTTCAACGGCCAAAGCCGTTGGATTTGATCGTGCTGAGATGGAAAAAATCTTAATTGAATTTGGTGAGCAAATG
GAAAGTGTTCTTAAGAAAGTGAGAGAACAATTACCCACAGATTTCCCTGAGCATATCGCAGACTCAATTCTATCCGGATT
ACATCACAAAGCAGCGAGATTAAATAAAGGCTGGGACTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9833.23 Da        Isoelectric Point: 10.9159

>AT170281 WP_197153101.1 NZ_CP060395:1550153-1550422 [Synechococcus sp. CBW1108]
MGMNIKDPQVHAMARELAARRSTTVTDAVRQALRAELARSSSPEAPRAVEAKKAAVRAICARFSARPEWQGRTSKELQDA
LYDDRGLPK

Download         Length: 270 bp

>AT170281 NZ_CP077260:c64917-64660 [Providencia rettgeri]
ATGAAAGTGACGAATACCCGACAACTTAGTGCTTATATGAAGGATGTCAGAGAGACGAAAAAGTTATCTCAAAGCAAAGT
CGCTAGCAAAGTAGGTATTCGGCAAGATACTGTTTCTAGCTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTTT
TTAAGATTTTATCTGCCCTCAATTTAGAACTTGATATTAAACCGCGAAATGAAAGCGGCTCATCAAATTCAGACTCCGGA
TGGAAGGAGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References