Detailed information of TA system TA170280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1473492..1474060
• Replicon: chromosome
• Accession: NZ_CP060395
• Organism: Synechococcus sp. CBW1108

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: H8F27_RS07830
• Protein ID: WP_197152934.1
• Coordinates: 1473722..1474060 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: H8F27_RS07825
• Protein ID: WP_197152927.1
• Coordinates: 1473492..1473728 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F27_RS07790	1468567..1470182	-	1616	Protein_1539	IS3 family transposase	-
H8F27_RS07795	1470223..1470570	+	348	WP_197152915.1	PIN domain-containing protein	-
H8F27_RS07800	1470880..1471008	-	129	WP_197152917.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H8F27_RS07805	1471012..1471281	-	270	WP_197152919.1	type II toxin-antitoxin system ParD family antitoxin	-
H8F27_RS07810	1471804..1472211	-	408	WP_197152921.1	hypothetical protein	-
H8F27_RS07815	1472282..1472680	-	399	WP_197152923.1	type II toxin-antitoxin system VapC family toxin	-
H8F27_RS07820	1472677..1472925	-	249	WP_197152925.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
H8F27_RS07825	1473492..1473728	+	237	WP_197152927.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
H8F27_RS07830	1473722..1474060	+	339	WP_197152934.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
H8F27_RS07835	1474475..1475134	+	660	WP_197152936.1	hypothetical protein	-
H8F27_RS07840	1475212..1475931	+	720	WP_197153440.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
H8F27_RS07845	1476180..1476767	-	588	WP_197152938.1	hypothetical protein	-
H8F27_RS07850	1476894..1477148	-	255	WP_197152940.1	hypothetical protein	-
H8F27_RS07855	1477617..1477841	-	225	WP_197152941.1	type II toxin-antitoxin system HicA family toxin	-
H8F27_RS07860	1477841..1478074	-	234	WP_197152943.1	type II toxin-antitoxin system HicB family antitoxin	-
H8F27_RS07865	1478381..1478761	-	381	WP_197152944.1	clan AA aspartic protease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-106)

Antitoxin

• Antitoxin PemI-like (2-78)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 11902.82 Da
• Isoelectric Point: 10.4152

>T170280 WP_197152934.1 NZ_CP060395:1473722-1474060 [Synechococcus sp. CBW1108]
VVRAPARGALIWLSFTPQSGREQAGRRPALVVSSSTYNSKVGLALVCPITSRVKGYPFEVALPEGGPVQGVVLADQLRSL
DWRSREAELIANAPIAVVERVLQLVGALLSSP

Nucleotide

• Length: 339 bp

>T170280 NZ_CP060395:1473722-1474060 [Synechococcus sp. CBW1108]
GTGGTGAGAGCACCGGCGCGCGGGGCTCTGATCTGGCTCAGCTTCACACCACAGAGTGGGCGTGAACAGGCTGGACGCCG
CCCGGCTTTGGTGGTGTCGTCATCGACGTACAACAGCAAGGTTGGCCTTGCTTTGGTGTGTCCCATCACCAGCAGGGTGA
AGGGATACCCATTTGAAGTGGCGCTGCCGGAAGGGGGGCCGGTGCAGGGGGTGGTGCTGGCGGATCAACTGCGCAGCCTG
GACTGGCGCAGCCGAGAGGCTGAGCTGATTGCCAATGCTCCGATTGCGGTGGTGGAGCGGGTGCTGCAGCTGGTTGGAGC
GCTGTTGAGCAGCCCGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8252.30 Da
• Isoelectric Point: 4.3903

>AT170280 WP_197152927.1 NZ_CP060395:1473492-1473728 [Synechococcus sp. CBW1108]
VKVKVQAWGNSLGLRIPKAYAAELGVGSGSEMELKVEAGALLARPAEAIHLDALLAEITAENQHSETDWGEPTGAEVW

Nucleotide

• Length: 237 bp

>AT170280 NZ_CP060395:1473492-1473728 [Synechococcus sp. CBW1108]
GTGAAAGTGAAGGTGCAGGCCTGGGGCAACAGCCTGGGGCTAAGGATCCCCAAGGCCTATGCCGCCGAGCTGGGTGTGGG
CTCTGGCAGTGAAATGGAGCTGAAGGTGGAGGCCGGTGCCTTGCTCGCCAGGCCCGCAGAGGCGATCCACCTGGATGCCC
TACTGGCTGAGATCACGGCTGAGAACCAACACAGCGAAACTGACTGGGGTGAGCCCACCGGTGCGGAGGTGTGGTGA