Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1030316..1030959 Replicon chromosome
Accession NZ_CP060395
Organism Synechococcus sp. CBW1108

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8F27_RS05620 Protein ID WP_197151982.1
Coordinates 1030561..1030959 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8F27_RS05615 Protein ID WP_197151981.1
Coordinates 1030316..1030552 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F27_RS05590 1026114..1026746 - 633 WP_197151965.1 alpha-ketoglutarate-dependent dioxygenase AlkB -
H8F27_RS05595 1026739..1027710 - 972 WP_197151973.1 RluA family pseudouridine synthase -
H8F27_RS05600 1027717..1028466 - 750 WP_197151975.1 response regulator transcription factor -
H8F27_RS05605 1028487..1028987 - 501 WP_197151977.1 hypothetical protein -
H8F27_RS05610 1029008..1030144 + 1137 WP_197151979.1 cysteine desulfurase -
H8F27_RS05615 1030316..1030552 + 237 WP_197151981.1 antitoxin Antitoxin
H8F27_RS05620 1030561..1030959 + 399 WP_197151982.1 type II toxin-antitoxin system VapC family toxin Toxin
H8F27_RS05625 1030994..1031503 - 510 WP_197151984.1 DUF456 family protein -
H8F27_RS05630 1031589..1032356 + 768 WP_197151985.1 hypothetical protein -
H8F27_RS05635 1032349..1033233 - 885 WP_197151986.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
H8F27_RS05640 1033226..1033831 - 606 WP_197151987.1 hypothetical protein -
H8F27_RS05645 1033932..1035116 + 1185 WP_197151988.1 NAD(P)H-quinone oxidoreductase subunit H -
H8F27_RS05650 1035151..1035513 + 363 WP_197153392.1 DUF2752 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(9-57)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14952.14 Da        Isoelectric Point: 8.5039

>T170278 WP_197151982.1 NZ_CP060395:1030561-1030959 [Synechococcus sp. CBW1108]
MLRYLLDTNICIYVIKRRPQELLSSFNRHASHMGISTITLAELLHGCEKSSDPSRNLAVVENFYSRLEVLAYGPKAAQHY
GQIRTDLERKGQPIGVNDLHIAAHARSEGLTLVSNNLREFNRVPGLLVENWI

Download         Length: 399 bp

>T170278 NZ_CP077259:1239638-1239988 [Streptococcus mitis]
ATGGATTATAAAAAATATCGGATTTTGTATTCTCCTAGAGTGATTGATAGTCTGGACAAAATATATCAGTATATAGCGGA
GGAAATTGGTTCTGTAGAGGCTGCGAGACGAAAAGTAGCCAGTATTAGAAAAGATATTAATCGTCTAGAAATTTTCCCCC
AAGCTGGATTTGATGCCGATGAAAAATTTGGTAAGAAATTAGACCCTCGCTACCAAACGCGAGGATTGACCTTGAGTAAG
GATTACATCGTATTATATACAATTGTTGAGGATACCGTCAGACTTGCTTATTTACTCCCTTCAAAAAGTGATTACATGAA
ATTATTCAAGACCAAGTCAAGATATGACTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8518.59 Da        Isoelectric Point: 4.9814

>AT170278 WP_197151981.1 NZ_CP060395:1030316-1030552 [Synechococcus sp. CBW1108]
MVAVTKLFLSNRSQAVRIPAPLRLPDSVTAVEVRACGQERIIAPVGSSWDSFFRDGPTASDDFLAERPSQGQSERESL

Download         Length: 237 bp

>AT170278 NZ_CP077259:1239361-1239648 [Streptococcus mitis]
ATGGCTATAGCGAATTCAAATAAAATTGTGACCTTCCAAGCTAATAGAGAATTGGTAAATGATGCCATGGAAGTGTTAAA
AGAACAAAATCTCTCTCTTTCATCAGCACTCAGATTATTTTTAAAGAATGTTGCCGTAACAAATGAAGTAGATTTACTGA
GTGAAGAGGAATTAGAGAAGGAGTATTTGTTTAGACAATTACAAGCAGAAGTTCAAGAAAGTTATGCCAAGATTGAGGCT
GGAAATTACTTGACAGATGAGGATGTCGTGACACGCTATGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References