Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1017757..1018430 Replicon chromosome
Accession NZ_CP060395
Organism Synechococcus sp. CBW1108

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8F27_RS05525 Protein ID WP_197151943.1
Coordinates 1017757..1018161 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8F27_RS05530 Protein ID WP_197151944.1
Coordinates 1018161..1018430 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F27_RS05485 1012765..1013049 + 285 WP_197151927.1 ribbon-helix-helix domain-containing protein -
H8F27_RS05490 1013046..1013504 + 459 WP_197151934.1 PIN domain-containing protein -
H8F27_RS05495 1013476..1013799 - 324 WP_197151936.1 nucleotidyltransferase domain-containing protein -
H8F27_RS05500 1013796..1014209 - 414 WP_197151938.1 nucleotidyltransferase substrate binding protein -
H8F27_RS05505 1014289..1014945 + 657 WP_197151940.1 adenylyl-sulfate kinase -
H8F27_RS05510 1014929..1016008 - 1080 WP_197151942.1 AI-2E family transporter -
H8F27_RS05515 1016008..1016502 - 495 WP_197153389.1 5-(carboxyamino)imidazole ribonucleotide mutase -
H8F27_RS05520 1016625..1017803 + 1179 WP_197153390.1 amidohydrolase family protein -
H8F27_RS05525 1017757..1018161 - 405 WP_197151943.1 type II toxin-antitoxin system VapC family toxin Toxin
H8F27_RS05530 1018161..1018430 - 270 WP_197151944.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H8F27_RS05535 1018524..1019240 + 717 WP_197151946.1 magnesium protoporphyrin IX methyltransferase -
H8F27_RS05540 1019260..1019856 + 597 WP_197151948.1 dihydroxyacetone kinase subunit L -
H8F27_RS05545 1019908..1020105 + 198 WP_197151950.1 hypothetical protein -
H8F27_RS05550 1020118..1020270 + 153 WP_197151953.1 hypothetical protein -
H8F27_RS05555 1020267..1020569 + 303 WP_197151955.1 HPr family phosphocarrier protein -
H8F27_RS05560 1020559..1022169 + 1611 WP_197151957.1 phosphoenolpyruvate--protein phosphotransferase -
H8F27_RS05565 1022231..1023262 + 1032 WP_197151959.1 dihydroxyacetone kinase subunit DhaK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-88)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14315.21 Da        Isoelectric Point: 4.5126

>T170277 WP_197151943.1 NZ_CP060395:c1018161-1017757 [Synechococcus sp. CBW1108]
MVIDTSAVLAILQDEPEGSAFNTVIAAAESCMLSAASLIELSIVLEARLGPDGQRDLDLFLSTAQINMVAVDRDQAELPR
RAFGRYGKGRHRAGLNFGDCFSYALAKGVGVPLLFKGNDFSHTDLESAWNPAAS

Download         Length: 405 bp

>T170277 NZ_CP077259:c317734-317369 [Streptococcus mitis]
GTGCATACGATTTACTTCTATAAGGACAAAAATGGAAATGAGCCAGTCTTGGATTATATGAGAGAATTGGCCTGTCGTAA
AAGTAAGGATAGCCGCATCAAACTCAATAAACTAAATGACTATATCGAGTTACTTAGTCAGCAAGGGACCAGAGCTGGGG
AACCTTATATGAAACACTTGGAAGATGAGATATGGGAACTAAGACCTTTGAGAGATCGAATTTTATTTGTAGCGTGGCTT
GATGGTAGTTTTGTTCTTTTACATCATTTTGTCAAAAAGACTCAGAAAACTCCTAGAAGAGAAATTGAAAAAGCCAAGCG
TGAACTGAAGGACTTAAAAGAAAGAGGGGTAAGTGATGAAGAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9776.10 Da        Isoelectric Point: 9.3125

>AT170277 WP_197151944.1 NZ_CP060395:c1018430-1018161 [Synechococcus sp. CBW1108]
MALNIRNPEANRLAAEVAALAGESNTVVVILAREERLQRLRRQQTARPDAQELLASRLDQIALSCAARPRRDQRTAEQIL
GYDAGGLPS

Download         Length: 270 bp

>AT170277 NZ_CP077259:c317379-317086 [Streptococcus mitis]
ATGAAGAATAGTGCTATTGGGAGTAACTGGAAGGATGTCAGGTCAGAACTCTTTACCAAGGAGGAAATACTTGAAAGTGA
TATGCGAGTGGCTATCATGAGTGAGTTGATTGAAGCCAGACATGAGCAAGGAATCAGCCAGAAAAAGCTAGAGGAACTCA
GTGGAGTGAGCCAGCCTGTCATAGCTAGGATGGAAACAGGAAAGACAAGTCCTCAGTTGGATACAGTCTTGAAAGTTTTA
GCCAGTTTAGGAAAGACACTAGCAGTCGTCCCACTTGAACAGAGAAAGAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References