Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 886336..887027 Replicon chromosome
Accession NZ_CP060395
Organism Synechococcus sp. CBW1108

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8F27_RS04760 Protein ID WP_197151674.1
Coordinates 886587..887027 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8F27_RS04755 Protein ID WP_197151667.1
Coordinates 886336..886587 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F27_RS04725 881393..881623 - 231 WP_197151650.1 DUF3136 domain-containing protein -
H8F27_RS04730 881958..882998 + 1041 WP_197151652.1 DUF4912 domain-containing protein -
H8F27_RS04735 883095..883265 + 171 WP_197151653.1 hypothetical protein -
H8F27_RS04740 883366..883602 + 237 WP_197151655.1 hypothetical protein -
H8F27_RS04745 884216..884911 + 696 WP_197151657.1 hypothetical protein -
H8F27_RS04750 884886..886217 - 1332 WP_197151665.1 cation:proton antiporter -
H8F27_RS04755 886336..886587 + 252 WP_197151667.1 hypothetical protein Antitoxin
H8F27_RS04760 886587..887027 + 441 WP_197151674.1 PIN domain-containing protein Toxin
H8F27_RS04765 887087..887512 + 426 WP_197151675.1 hypothetical protein -
H8F27_RS04770 887560..887826 + 267 WP_197151676.1 plasmid stabilization protein -
H8F27_RS04775 887823..888237 + 415 Protein_944 type II toxin-antitoxin system VapC family toxin -
H8F27_RS04780 888395..889318 + 924 WP_197151677.1 AEC family transporter -
H8F27_RS04785 889495..889716 + 222 WP_197151678.1 hypothetical protein -
H8F27_RS04790 889713..890336 + 624 WP_197151679.1 potassium channel family protein -
H8F27_RS04795 890285..890689 - 405 WP_197151680.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(4-139)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16032.55 Da        Isoelectric Point: 6.4780

>T170275 WP_197151674.1 NZ_CP060395:886587-887027 [Synechococcus sp. CBW1108]
MGRALLDINVLIALLDQGHLLHRPATRWLEGQLEQGWATCPITENGVVRIIAQPAYPNAQPAALVAARLAEACSHSSHMF
WPEPISLLQEGLIRWERLLGPRQITDAYLLALAASQGGRFASFDQRITLEVVPSAEAHHLCLIPCS

Download         Length: 441 bp

>T170275 NZ_CP077242:c4238049-4237946 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8630.66 Da        Isoelectric Point: 4.9816

>AT170275 WP_197151667.1 NZ_CP060395:886336-886587 [Synechococcus sp. CBW1108]
MRTTLDIEDDVLAAARELARRQGTTAGQVVSRLLRAALSGAPSTGQAAAEAPPSAAGFRPFQARAGVVVTNEQIDQLRDE
AGL

Download         Length: 252 bp

>AT170275 NZ_CP077242:4237908-4238176 [Escherichia fergusonii]
AAAGTCAGCGAATGGAATATTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References