Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 411254..411885 Replicon chromosome
Accession NZ_CP060395
Organism Synechococcus sp. CBW1108

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag H8F27_RS02150 Protein ID WP_197150933.1
Coordinates 411254..411634 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag H8F27_RS02155 Protein ID WP_197150940.1
Coordinates 411631..411885 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F27_RS02130 406535..407530 + 996 WP_197150928.1 DUF952 domain-containing protein -
H8F27_RS02135 407594..409297 + 1704 WP_197150930.1 glutaminase A -
H8F27_RS02140 409298..410407 - 1110 WP_197150931.1 IS630 family transposase -
H8F27_RS02145 410565..410948 - 384 WP_197153303.1 type II toxin-antitoxin system VapC family toxin -
H8F27_RS02150 411254..411634 - 381 WP_197150933.1 type II toxin-antitoxin system VapC family toxin Toxin
H8F27_RS02155 411631..411885 - 255 WP_197150940.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H8F27_RS02160 412403..412594 + 192 WP_197150942.1 hypothetical protein -
H8F27_RS02165 412705..413951 - 1247 Protein_430 group II intron reverse transcriptase/maturase -
H8F27_RS02170 414572..414988 - 417 Protein_431 helix-turn-helix domain-containing protein -
H8F27_RS02175 415638..416003 + 366 WP_197150943.1 YraN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 409298..410407 1109


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-117)

Antitoxin

SpoVT-AbrB domain

(9-27)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13801.73 Da        Isoelectric Point: 6.0688

>T170274 WP_197150933.1 NZ_CP060395:c411634-411254 [Synechococcus sp. CBW1108]
VIYLSKNRPPQVAQRIDALGDDDSIAMSFITWAELLRGAEGSQRREATLQHLEALSRLAPVLYPQGPGICEHYAVQATAL
KRRATPIDANDLWIACHALAIGATVVSHNVSEFSRVEGLQLVDWAV

Download         Length: 381 bp

>T170274 NZ_CP077242:3980025-3980303 [Escherichia fergusonii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGTGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATCTCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCTGATAACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9420.62 Da        Isoelectric Point: 4.5183

>AT170274 WP_197150940.1 NZ_CP060395:c411885-411631 [Synechococcus sp. CBW1108]
MDVLPSRVFMNGNSQAVRIPAEFRLSSDRVQISRTPEGDLLIHPCPSQRGQALLQALSSFDADFVEALEQEQQNKLPVQE
REAL

Download         Length: 255 bp

>AT170274 NZ_CP077242:3980303-3980587 [Escherichia fergusonii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAGCTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCGGCATTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTAGATGTGTCGCGACTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References