Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 6028384..6029039 Replicon chromosome
Accession NZ_CP060394
Organism Acidobacterium sp. 4Y35

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H7849_RS25390 Protein ID WP_186743234.1
Coordinates 6028650..6029039 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H7849_RS25385 Protein ID WP_186743233.1
Coordinates 6028384..6028650 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7849_RS25360 6023505..6024758 - 1254 WP_186743228.1 glucose-1-phosphate adenylyltransferase -
H7849_RS25365 6024919..6025218 - 300 WP_186743229.1 hypothetical protein -
H7849_RS25370 6025300..6025788 + 489 WP_186743230.1 hypothetical protein -
H7849_RS25375 6025844..6027418 + 1575 WP_186743231.1 methylmalonyl-CoA mutase -
H7849_RS25380 6027802..6028263 + 462 WP_186743232.1 hypothetical protein -
H7849_RS25385 6028384..6028650 + 267 WP_186743233.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H7849_RS25390 6028650..6029039 + 390 WP_186743234.1 type II toxin-antitoxin system VapC family toxin Toxin
H7849_RS25395 6029165..6029923 + 759 WP_186743235.1 TIGR00266 family protein -
H7849_RS25400 6030231..6031214 - 984 WP_186747875.1 ROK family protein -
H7849_RS25405 6031446..6032528 + 1083 WP_186743236.1 FtsQ-type POTRA domain-containing protein -
H7849_RS25410 6032525..6033739 + 1215 WP_186743237.1 cell division protein FtsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-87)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14316.52 Da        Isoelectric Point: 7.8568

>T170273 WP_186743234.1 NZ_CP060394:6028650-6029039 [Acidobacterium sp. 4Y35]
MVLDTSAILAVLLEEPEAAQLVHFIGEDRIRLCSAVSFVEASIVLRNRKGERGRQKLDQFLRRARVQITAVDVKQAEVAR
EAYEKFGKGKHPAGLNLGDCFSYALAKTTNEPLLFKGEDFVKTDVVSVP

Download         Length: 390 bp

>T170273 NZ_CP077242:3377195-3377449 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9673.99 Da        Isoelectric Point: 5.7121

>AT170273 WP_186743233.1 NZ_CP060394:6028384-6028650 [Acidobacterium sp. 4Y35]
VPLYIKNPNVEKSARRLARLTGETLTEATERAIEERLARLRPAQSPAHGATQLEKDLLRIAHQCAALPDVDTRMADEILG
YDAEGLPG

Download         Length: 267 bp

>AT170273 NZ_CP077242:3376947-3377198 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACGGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References