Detailed information of TA system TA170272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4759601..4760262
• Replicon: chromosome
• Accession: NZ_CP060394
• Organism: Acidobacterium sp. 4Y35

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H7849_RS19740
• Protein ID: WP_186741831.1
• Coordinates: 4759601..4760035 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H7849_RS19745
• Protein ID: WP_186741833.1
• Coordinates: 4760032..4760262 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7849_RS19720	4756518..4757192	+	675	WP_186741824.1	alpha/beta fold hydrolase	-
H7849_RS19725	4757274..4757633	-	360	WP_186741826.1	DUF1493 family protein	-
H7849_RS19730	4757865..4758452	+	588	WP_186741828.1	histidine phosphatase family protein	-
H7849_RS19735	4758618..4759175	-	558	WP_186741830.1	hypothetical protein	-
H7849_RS19740	4759601..4760035	-	435	WP_186741831.1	PIN domain-containing protein	Toxin
H7849_RS19745	4760032..4760262	-	231	WP_186741833.1	CopG family transcriptional regulator	Antitoxin
H7849_RS19750	4760331..4761176	+	846	WP_186747675.1	tRNA glutamyl-Q(34) synthetase GluQRS	-
H7849_RS19755	4761354..4762274	+	921	WP_186741835.1	transposase	-
H7849_RS19760	4762654..4763268	-	615	WP_186741837.1	DinB family protein	-
H7849_RS19765	4763473..4764630	+	1158	WP_186741665.1	IS481 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16085.41 Da
• Isoelectric Point: 6.6939

>T170272 WP_186741831.1 NZ_CP060394:c4760035-4759601 [Acidobacterium sp. 4Y35]
VTRFLLDINVLIALIDPVHVQHDRAHEWFASKGRMAWATCPLTENGVVRIVGHLRYPNSPGSPAAVADLLTSFRKLPGHM
FWPDDLSLFDREHVTADRLLDSAQVTDSYLLALARAHEGQLATFDQRLVTDAVMNGPQALHVIR

Nucleotide

• Length: 435 bp

>T170272 NZ_CP077242:3376947-3377198 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACGGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8275.65 Da
• Isoelectric Point: 8.8086

>AT170272 WP_186741833.1 NZ_CP060394:c4760262-4760032 [Acidobacterium sp. 4Y35]
MRTTLSIDDDVLSAAKEMAAMEKKSVGEVISALARRALVPVASKAETRNGVPLLEVRKGATRVTSELVHQLREELM

Nucleotide

• Length: 231 bp

>AT170272 NZ_CP077242:3377195-3377449 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA