Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1281295..1281857 Replicon chromosome
Accession NZ_CP060394
Organism Acidobacterium sp. 4Y35

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H7849_RS05190 Protein ID WP_186744721.1
Coordinates 1281295..1281663 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H7849_RS05195 Protein ID WP_186744723.1
Coordinates 1281660..1281857 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7849_RS05160 1276537..1276908 - 372 WP_186744712.1 VOC family protein -
H7849_RS05165 1276977..1277768 - 792 WP_186744714.1 transporter -
H7849_RS05170 1277906..1278844 + 939 WP_186744715.1 glycosyltransferase -
H7849_RS05175 1279016..1280383 + 1368 WP_186744717.1 lipopolysaccharide biosynthesis protein -
H7849_RS05180 1280388..1280666 - 279 WP_186747213.1 DUF1801 domain-containing protein -
H7849_RS05185 1280838..1281233 - 396 WP_186744719.1 VOC family protein -
H7849_RS05190 1281295..1281663 - 369 WP_186744721.1 type II toxin-antitoxin system VapC family toxin Toxin
H7849_RS05195 1281660..1281857 - 198 WP_186744723.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H7849_RS05200 1282009..1284405 - 2397 WP_186747215.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13793.07 Da        Isoelectric Point: 10.0851

>T170271 WP_186744721.1 NZ_CP060394:c1281663-1281295 [Acidobacterium sp. 4Y35]
MILADTSIWVDHFRKRDAELQHQLLQNNIATHPFVVTELALGSLPDRRKTLADLELLPKVRIAQTDEVRAMIEFRKLFRK
GLGFVDAHLIAAALITPGTILWSRDKQLHSIAQSMGISHAHP

Download         Length: 369 bp

>T170271 NZ_CP077242:c2851655-2851437 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7187.40 Da        Isoelectric Point: 10.6985

>AT170271 WP_186744723.1 NZ_CP060394:c1281857-1281660 [Acidobacterium sp. 4Y35]
MRTTVALDDELIKKAQEYTGLKENSALLREALKALLEREAARRLADLGGAAPKMAHIPRRKTKTG

Download         Length: 198 bp

>AT170271 NZ_CP077242:c2852056-2851682 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References