Detailed information of TA system TA170270

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 1013515..1014127
• Replicon: chromosome
• Accession: NZ_CP060393
• Organism: Edaphobacter sp. 4G125

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H7846_RS04170
• Protein ID: WP_186695266.1
• Coordinates: 1013951..1014127 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H7846_RS04165
• Protein ID: WP_186695265.1
• Coordinates: 1013515..1013943 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7846_RS04120	1009371..1009580	+	210	WP_186695256.1	hypothetical protein	-
H7846_RS04125	1009620..1009946	-	327	WP_186695257.1	hypothetical protein	-
H7846_RS04130	1010088..1010324	-	237	WP_186695258.1	hypothetical protein	-
H7846_RS04135	1010458..1010955	+	498	WP_186695259.1	hypothetical protein	-
H7846_RS04140	1010972..1011349	+	378	WP_186695260.1	HNH endonuclease	-
H7846_RS04145	1011487..1012248	+	762	WP_186695261.1	DUF2786 domain-containing protein	-
H7846_RS04150	1012248..1012775	+	528	WP_186695262.1	hypothetical protein	-
H7846_RS04155	1012816..1013088	-	273	WP_186695263.1	hypothetical protein	-
H7846_RS04160	1013135..1013440	-	306	WP_186695264.1	hypothetical protein	-
H7846_RS04165	1013515..1013943	-	429	WP_186695265.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H7846_RS04170	1013951..1014127	-	177	WP_186695266.1	type II toxin-antitoxin system HicA family toxin	Toxin
H7846_RS04175	1015191..1016270	+	1080	WP_186695267.1	hypothetical protein	-
H7846_RS04180	1016379..1017500	+	1122	WP_186695268.1	DNA cytosine methyltransferase	-
H7846_RS04185	1017801..1017995	+	195	WP_186695269.1	hypothetical protein	-
H7846_RS04190	1018013..1018417	+	405	WP_186695270.1	hypothetical protein	-
H7846_RS04195	1018454..1018630	+	177	WP_186695271.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1003665..1043195	39530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-93)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6404.55 Da
• Isoelectric Point: 11.1590

>T170270 WP_186695266.1 NZ_CP060393:c1014127-1013951 [Edaphobacter sp. 4G125]
MKSSEFKRWLTEQGANFKPGKGSHLKVTLNGKQSVLPMHNKELGTGLVNAIKKQLGLK

Nucleotide

• Length: 177 bp

>T170270 NZ_CP077242:2627908-2628315 [Escherichia fergusonii]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACTCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 16099.59 Da
• Isoelectric Point: 7.3195

>AT170270 WP_186695265.1 NZ_CP060393:c1013943-1013515 [Edaphobacter sp. 4G125]
MMRYPIKMRRDDNYFLVTFPDIPEAITQGRTEEEALEAAKDALETALDFYFDDGREVPEPSPLKKRQAFVELPVSVSAKV
LLLNEMIRQKVRPVELARRLHTTPQEVNRLVNIRHTSKIDGIASALKALGKTLHITTLSDAA

Nucleotide

• Length: 429 bp

>AT170270 NZ_CP077242:2627661-2627927 [Escherichia fergusonii]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGTGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA