Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3264254..3265475 Replicon chromosome
Accession NZ_CP060392
Organism Pseudomonas aeruginosa strain 1903031130

Toxin (Protein)


Gene name vapC Uniprot ID V6AG16
Locus tag H8A93_RS15570 Protein ID WP_003088107.1
Coordinates 3264254..3264832 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8A93_RS15575 Protein ID WP_003088112.1
Coordinates 3264921..3265475 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8A93_RS15555 3259530..3260807 + 1278 WP_003088104.1 TolC family protein -
H8A93_RS15560 3260797..3262968 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
H8A93_RS15565 3262958..3264145 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
H8A93_RS15570 3264254..3264832 - 579 WP_003088107.1 HD domain-containing protein Toxin
H8A93_RS15575 3264921..3265475 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
H8A93_RS15580 3265633..3267828 - 2196 WP_003088114.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
H8A93_RS15585 3267833..3268294 - 462 WP_003088117.1 (2Fe-2S)-binding protein -
H8A93_RS15590 3268625..3268948 + 324 WP_003102734.1 multidrug efflux SMR transporter -
H8A93_RS15595 3268961..3269359 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
H8A93_RS15600 3269356..3269907 - 552 WP_023098678.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-187)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21885.74 Da        Isoelectric Point: 5.3655

>T170266 WP_003088107.1 NZ_CP060392:c3264832-3264254 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Download         Length: 579 bp

>T170266 NZ_CP077242:1897879-1898031 [Escherichia fergusonii]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGAGAATTATGAGCTGGCGGCGTTTTTAGCCTGCAAATTGAAAGAGTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT170266 WP_003088112.1 NZ_CP060392:c3265475-3264921 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT170266 NZ_CP077242:c1897822-1897774 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AG16

Antitoxin

Source ID Structure

References