Detailed information of TA system TA170259

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YefM
• Location: 33250..33778
• Replicon: chromosome
• Accession: NZ_CP060390
• Organism: Psychrobacter sp. KCTC 72983

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1R4K033
• Locus tag: PSBA01_RS00130
• Protein ID: WP_071001399.1
• Coordinates: 33491..33778 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PSBA01_RS00125
• Protein ID: WP_186474690.1
• Coordinates: 33250..33501 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PSBA01_RS00110	28652..29053	+	402	WP_083328796.1	DUF493 domain-containing protein	-
PSBA01_RS00115	29553..31829	+	2277	WP_186474688.1	ribonucleoside-diphosphate reductase subunit alpha	-
PSBA01_RS00120	31924..32805	+	882	WP_186474689.1	P63C domain-containing protein	-
PSBA01_RS00125	33250..33501	+	252	WP_186474690.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PSBA01_RS00130	33491..33778	+	288	WP_071001399.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
PSBA01_RS00135	33818..34189	+	372	WP_186474691.1	hypothetical protein	-
PSBA01_RS00140	34287..35420	+	1134	WP_186474692.1	ribonucleotide-diphosphate reductase subunit beta	-
PSBA01_RS00145	35588..35857	+	270	WP_071001396.1	2Fe-2S iron-sulfur cluster binding domain-containing protein	-
PSBA01_RS00150	35984..37315	-	1332	WP_071001395.1	trypsin-like peptidase domain-containing protein	-
PSBA01_RS00155	37707..38543	+	837	WP_186474693.1	Nif3-like dinuclear metal center hexameric protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-68)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11014.87 Da
• Isoelectric Point: 10.5715

>T170259 WP_071001399.1 NZ_CP060390:33491-33778 [Psychrobacter sp. KCTC 72983]
MTYSLEFHPLALKEWKKIAPSIQQQFKKKLQQRLSNPHVPASKLSGHTDTYKIKLRTIGYRLVYTVKDDVVVVYVLAVGK
RENNKVYDSLATRQP

Nucleotide

• Length: 288 bp

>T170259 NZ_CP077240:4619-4906 [Acinetobacter pittii]
ATGGAACTGTATTTCGAATGGGATGAGGCTAAAAACCAAAAGAATCAGAAAAAACATGATGTATCTTTTGAAACGGCAAG
CCTCGTTTTTGAAGATCCTTTACGGATCTCAATCCAGGATCGACATACCAATGGTGAAGAACGTTGGCAAACGATCGGTA
TGGTTAAAGGTGTACTGATGTTATTGGTGGCTCATACAATCATTGACGATGATGACTGTGAGATCATACGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAACGCAATCAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9096.36 Da
• Isoelectric Point: 4.2493

>AT170259 WP_186474690.1 NZ_CP060390:33250-33501 [Psychrobacter sp. KCTC 72983]
MQPIFATQTASISELKNNPSALIKQSDGESIAILNHNKPVAYLVSTDVFERMMEAMDDMALSQTVNARMNDGQAPIKVTL
DDL

Nucleotide

• Length: 252 bp

>AT170259 NZ_CP077240:4893-5204 [Acinetobacter pittii]
ATGAGCATGGTTAGATATACACGCAAAGAACTGAATGAAAAATTCAGTGACAAGCAAGATGCTGAAATTAAACGCTTGCT
TGCAAAAGGAACTGTACCAGATGAACAATTAGATCTATCTGACATTCCTGAGATTACCGACTGGAGTCATGCTGTTCGCC
ATGGGCAATTTTATCGTCCAGTGAAGCAACAAACATCTGTTCGTCTAGATGCAGATGTACTTGCATGGTTAAAGGCTCAA
GGCAAAGGCTATCAGACACGCATGAATAAAATTCTGCGTGAAGCAATGCTAGAAGATCTTAAGAATCATTGA

Structures

Toxin

• AlphaFold DB: A0A1R4K033