Detailed information of TA system TA170258

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 3659839..3660389
• Replicon: chromosome
• Accession: NZ_CP060388
• Organism: Sphingobium sp. KCTC 72723

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SPBM01_RS17670
• Protein ID: WP_188062838.1
• Coordinates: 3660087..3660389 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: SPBM01_RS17665
• Protein ID: WP_188062837.1
• Coordinates: 3659839..3660084 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPBM01_RS17630	3655845..3656354	-	510	WP_188062833.1	SRPBCC domain-containing protein	-
SPBM01_RS17635	3656454..3657368	+	915	WP_188062834.1	LysR family transcriptional regulator	-
SPBM01_RS17640	3657403..3658023	-	621	WP_188062835.1	LysE family translocator	-
SPBM01_RS17645	3658020..3658400	-	381	WP_188065799.1	PaaI family thioesterase	-
SPBM01_RS17650	3658481..3659206	-	726	WP_188062836.1	3-methyl-2-oxobutanoate hydroxymethyltransferase	-
SPBM01_RS17655	3659224..3659388	+	165	Protein_3478	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
SPBM01_RS17660	3659461..3659634	-	174	Protein_3479	integrase	-
SPBM01_RS17665	3659839..3660084	+	246	WP_188062837.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
SPBM01_RS17670	3660087..3660389	+	303	WP_188062838.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPBM01_RS17675	3660818..3661717	+	900	WP_188065800.1	hypothetical protein	-
SPBM01_RS17680	3662024..3662272	-	249	WP_188062839.1	BrnA antitoxin family protein	-
SPBM01_RS17685	3662241..3662516	-	276	WP_188062840.1	BrnT family toxin	-
SPBM01_RS17690	3662590..3662949	-	360	Protein_3485	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3662773..3662949	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

• Antitoxin ParD (6-64)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11422.94 Da
• Isoelectric Point: 5.1259

>T170258 WP_188062838.1 NZ_CP060388:3660087-3660389 [Sphingobium sp. KCTC 72723]
VPRFRLTRAAADDLATIFLKGIEQFGLPQADTYHEGLSAIFAFLAEYPQAARLREEISPPVRVHPYKAHLVIYDVGDEDE
VIILRVRHGREDWMPSNYDG

Nucleotide

• Length: 303 bp

>T170258 NZ_CP077239:17110-17466 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9057.15 Da
• Isoelectric Point: 4.7265

>AT170258 WP_188062837.1 NZ_CP060388:3659839-3660084 [Sphingobium sp. KCTC 72723]
MATMNISLPDPMKQWVEAQADTGRYSNASDYVRDLIRRDQERADKVAVMQRLVDEARASGLSDETMADIRTRAISQAGLQ
A

Nucleotide

• Length: 246 bp

>AT170258 NZ_CP077239:17459-17761 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA