Detailed information of TA system TA170257

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1660367..1660926
• Replicon: chromosome
• Accession: NZ_CP060388
• Organism: Sphingobium sp. KCTC 72723

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SPBM01_RS08330
• Protein ID: WP_188065003.1
• Coordinates: 1660367..1660660 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SPBM01_RS08335
• Protein ID: WP_188065005.1
• Coordinates: 1660648..1660926 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPBM01_RS08315	1656328..1658178	+	1851	WP_188065000.1	dihydroxy-acid dehydratase	-
SPBM01_RS08320	1658295..1659137	-	843	WP_188065620.1	S-formylglutathione hydrolase	-
SPBM01_RS08325	1659140..1660249	-	1110	WP_188065001.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
SPBM01_RS08330	1660367..1660660	-	294	WP_188065003.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPBM01_RS08335	1660648..1660926	-	279	WP_188065005.1	CopG family ribbon-helix-helix protein	Antitoxin
SPBM01_RS08340	1661006..1662724	-	1719	WP_188065007.1	acyl-CoA dehydrogenase	-
SPBM01_RS08345	1662825..1663436	-	612	WP_188065621.1	TetR/AcrR family transcriptional regulator	-
SPBM01_RS08350	1663402..1664106	-	705	WP_188065009.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11056.79 Da
• Isoelectric Point: 9.7847

>T170257 WP_188065003.1 NZ_CP060388:c1660660-1660367 [Sphingobium sp. KCTC 72723]
VSRLIWTAEALADVQRLYRWLLPKDAEAAKRAVGAIRAGVRILAQQPRIGRPVEDMDPEYREKPIDFGNSGYVVLYRVEQ
DVVVLLAVRHRKEAGYP

Nucleotide

• Length: 294 bp

>T170257 NZ_CP077238:3834273-3834662 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCTTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCCCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGCGCGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATCTTGAAGAAACTCCTACGAACATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAGCTCTATTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10606.82 Da
• Isoelectric Point: 4.7494

>AT170257 WP_188065005.1 NZ_CP060388:c1660926-1660648 [Sphingobium sp. KCTC 72723]
MVTATSIKLDEDMKGRVQHLAEARRRSSHWIMREAIAQYVEREEKREALKQDAMQAWEGYQQTGLHLSVDEADSWLARLE
AGEDADLPPCHD

Nucleotide

• Length: 279 bp

>AT170257 NZ_CP077238:3834009-3834266 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCGGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA