Detailed information of TA system TA170254

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 774075..775797
• Replicon: chromosome
• Accession: NZ_CP060386
• Organism: Vibrio alginolyticus strain Vb1833

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: H7696_RS03650
• Protein ID: WP_186584680.1
• Coordinates: 774859..775797 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: H7696_RS03645
• Protein ID: WP_186584679.1
• Coordinates: 774075..774866 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7696_RS03615	769748..770029	+	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
H7696_RS03620	770026..770652	+	627	WP_000667167.1	hypothetical protein	-
H7696_RS03625	770636..771532	+	897	WP_186585020.1	type-F conjugative transfer system secretin TraK	-
H7696_RS03630	771535..772824	+	1290	WP_186584678.1	TraB/VirB10 family protein	-
H7696_RS03635	772899..773471	+	573	WP_001944091.1	type IV conjugative transfer system lipoprotein TraV	-
H7696_RS03640	773468..773854	+	387	WP_000180225.1	hypothetical protein	-
H7696_RS03645	774075..774866	+	792	WP_186584679.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
H7696_RS03650	774859..775797	+	939	WP_186584680.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H7696_RS03655	776290..776946	-	657	WP_025611037.1	hypothetical protein	-
H7696_RS03660	776990..777136	-	147	WP_162838621.1	hypothetical protein	-
H7696_RS03665	777378..778070	+	693	WP_001228924.1	DsbC family protein	-
H7696_RS03670	778070..780481	+	2412	WP_140077947.1	type IV secretion system protein TraC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(59) / floR / aph(6)-Id / aph(3'')-Ib / sul2 / qnrVC1 / blaVIM-4 / blaVEB-1 / ant(2'')-Ia / ARR-3 / ere(A)	-	707653..852689	145036
	-	flank	IS/Tn	-	-	780544..781647	1103

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35506.74 Da
• Isoelectric Point: 4.9081

>T170254 WP_186584680.1 NZ_CP060386:774859-775797 [Vibrio alginolyticus]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLANANAE

Nucleotide

• Length: 939 bp

>T170254 NZ_CP077236:c4385593-4385503 [Lelliottia amnigena]
AGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATACAGGAATCGTATTC
GGTCTCTTTTT

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30102.47 Da
• Isoelectric Point: 9.1901

>AT170254 WP_186584679.1 NZ_CP060386:774075-774866 [Vibrio alginolyticus]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT170254 NZ_CP077236:4385498-4385672 [Lelliottia amnigena]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAACTACGCCTGACACTCTAAGAATAGATGACGACGCCAGGTTTTCCAGTCCGCGACTAAAGTGG
TCAGAAAAAAAGCGT