Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 4384779..4385344 | Replicon | chromosome |
Accession | NZ_CP060298 | ||
Organism | Nakamurella sp. PAMC28650 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | - |
Locus tag | H7F38_RS19830 | Protein ID | WP_187094836.1 |
Coordinates | 4384779..4385129 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | - |
Locus tag | H7F38_RS19835 | Protein ID | WP_090480857.1 |
Coordinates | 4385126..4385344 (-) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H7F38_RS19810 | 4380319..4380726 | - | 408 | WP_187091423.1 | ester cyclase | - |
H7F38_RS19815 | 4380958..4381620 | + | 663 | WP_187091424.1 | TetR/AcrR family transcriptional regulator | - |
H7F38_RS19820 | 4382504..4383355 | + | 852 | WP_187091425.1 | GAF and ANTAR domain-containing protein | - |
H7F38_RS19825 | 4383807..4384589 | + | 783 | WP_187091426.1 | alpha/beta fold hydrolase | - |
H7F38_RS19830 | 4384779..4385129 | - | 351 | WP_187094836.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
H7F38_RS19835 | 4385126..4385344 | - | 219 | WP_090480857.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
H7F38_RS19840 | 4386030..4387001 | - | 972 | WP_187091427.1 | IS1595 family transposase | - |
H7F38_RS19855 | 4388514..4389713 | - | 1200 | WP_187091428.1 | site-specific integrase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12473.44 Da Isoelectric Point: 11.1777
>T170253 WP_187094836.1 NZ_CP060298:c4385129-4384779 [Nakamurella sp. PAMC28650]
MMRRGEIRLVDLDPVRGSEANKQRPAVVVSNDRANSVAQRLGRGVVTVVPLTSNTARVFPFQVLIPADAVGLRVASKAQA
EQVRSVAVERVGPSLGLLQASLLAEIDDALRLHLDL
MMRRGEIRLVDLDPVRGSEANKQRPAVVVSNDRANSVAQRLGRGVVTVVPLTSNTARVFPFQVLIPADAVGLRVASKAQA
EQVRSVAVERVGPSLGLLQASLLAEIDDALRLHLDL
Download Length: 351 bp
>T170253 NZ_CP077236:c4003975-4002668 [Lelliottia amnigena]
ATGAAAACCAGTAAGCTGACCGTTGCGATGAACGGTACGGTTGTCGGCACGCTGTATCGTAATGGAAAAGGGGCAATGTC
CTGGCAATATGCGCAGACATGGCTCGACACGCCGGGCGCGCGCGTGATTTCACAGTCGCTACCGTTAACGCCGCGTCGTC
AGGAAGGCGAGGTGGTGTATAACTTCTTTAGTAATTTGCTGCCTGACTCGCAGGCGATTATCTCGCGTATGCAAACGCGC
TTTAAAATCCCCACGGATCATCCCTTCGATTTGCTGGCAAGCGTTGGCCGCGACTGTGTTGGGGCAATCCAGCTCTACCC
GGAAAACAGTGAAATACCCCCTGTGACGCACATGCAGGCCACGCCGCTTTCCGATAACGAGATTGCGGCACTGCTGGAAG
GGTATCGTAATGCGCCATTGGGGATGAATGACGACCAGGATTTCAGGATTTCCATTGCAGGTGCGCAGGAAAAAACGGCA
CTGCTCTGGCATCAGAACCGCTGGCAACGCCCCAACGGCAGCACGCCCACCAGCCATATTTTCAAACTGCCCATCGGTAA
AATTGAGCAGAACAATATCGATCTGAGTGAAAGCTGCGAGAACGAATGGCTGTGTCTGCGCCTTGCCCGTGAATTCGGTT
TTTCGGTCGCCGAGGCAACGTTAGCAACCTATGCCGACAAAAAAGTGCTGATTGTTGAGCGTTTTGATCGTAAATGGTCA
CGAGACGGAAAGTGGCTGATGCGACTCCCGCAAGAAGATATGTGTCAGGCTCTCGGGTATTCACCGGCGCTGAAATATGA
ATCTCACGGCGGCCCCGGCATCGCCGAAATCATGACCTTGCTGTTGGGATCGCGCCGCTCAAACCAGGATCGCGAAACGT
TTTTCCGCACTCAGATATTTTACTGGCTGACAGGCGCGATCGATGGCCACGCAAAAAATTACAGTGTGTTTATCGAACCC
GATTCGGCGTACGTTATGACGCCGCTATACGATATTTTGTCAGCCTATCCGGTCTTCGGGCCAAAAGGAATTTCCGCACA
AAAAGCGAAAATGGCCATGGCGTTGCAGGGCAAAAACCGGCAATACCACTGGGCTCAGATTCAACCACGCCATTTCCCGG
CTACGGCTGAACGCGTTGGTTTTTCAGCTATACGCGCAAAAAAGATGATGATCGAAATGGGAAATGCGACAAATGAGATT
ATCGAGCGGGTACGTCAGTCGTTACCGATTGATTTCCCGACACATATCAGCGAAGCGATTTTTAACGGGATGGCGAAGCA
AGCTGAAAGGCTAATACGTTTAGAATAA
ATGAAAACCAGTAAGCTGACCGTTGCGATGAACGGTACGGTTGTCGGCACGCTGTATCGTAATGGAAAAGGGGCAATGTC
CTGGCAATATGCGCAGACATGGCTCGACACGCCGGGCGCGCGCGTGATTTCACAGTCGCTACCGTTAACGCCGCGTCGTC
AGGAAGGCGAGGTGGTGTATAACTTCTTTAGTAATTTGCTGCCTGACTCGCAGGCGATTATCTCGCGTATGCAAACGCGC
TTTAAAATCCCCACGGATCATCCCTTCGATTTGCTGGCAAGCGTTGGCCGCGACTGTGTTGGGGCAATCCAGCTCTACCC
GGAAAACAGTGAAATACCCCCTGTGACGCACATGCAGGCCACGCCGCTTTCCGATAACGAGATTGCGGCACTGCTGGAAG
GGTATCGTAATGCGCCATTGGGGATGAATGACGACCAGGATTTCAGGATTTCCATTGCAGGTGCGCAGGAAAAAACGGCA
CTGCTCTGGCATCAGAACCGCTGGCAACGCCCCAACGGCAGCACGCCCACCAGCCATATTTTCAAACTGCCCATCGGTAA
AATTGAGCAGAACAATATCGATCTGAGTGAAAGCTGCGAGAACGAATGGCTGTGTCTGCGCCTTGCCCGTGAATTCGGTT
TTTCGGTCGCCGAGGCAACGTTAGCAACCTATGCCGACAAAAAAGTGCTGATTGTTGAGCGTTTTGATCGTAAATGGTCA
CGAGACGGAAAGTGGCTGATGCGACTCCCGCAAGAAGATATGTGTCAGGCTCTCGGGTATTCACCGGCGCTGAAATATGA
ATCTCACGGCGGCCCCGGCATCGCCGAAATCATGACCTTGCTGTTGGGATCGCGCCGCTCAAACCAGGATCGCGAAACGT
TTTTCCGCACTCAGATATTTTACTGGCTGACAGGCGCGATCGATGGCCACGCAAAAAATTACAGTGTGTTTATCGAACCC
GATTCGGCGTACGTTATGACGCCGCTATACGATATTTTGTCAGCCTATCCGGTCTTCGGGCCAAAAGGAATTTCCGCACA
AAAAGCGAAAATGGCCATGGCGTTGCAGGGCAAAAACCGGCAATACCACTGGGCTCAGATTCAACCACGCCATTTCCCGG
CTACGGCTGAACGCGTTGGTTTTTCAGCTATACGCGCAAAAAAGATGATGATCGAAATGGGAAATGCGACAAATGAGATT
ATCGAGCGGGTACGTCAGTCGTTACCGATTGATTTCCCGACACATATCAGCGAAGCGATTTTTAACGGGATGGCGAAGCA
AGCTGAAAGGCTAATACGTTTAGAATAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8043.81 Da Isoelectric Point: 4.4406
>AT170253 WP_090480857.1 NZ_CP060298:c4385344-4385126 [Nakamurella sp. PAMC28650]
MKLSVSLPDDDVAVLDEHARRAGLGSRSAALHQAIRLLRRSSLEDDYAAAWEDWDRSGEREMWETTASDGLS
MKLSVSLPDDDVAVLDEHARRAGLGSRSAALHQAIRLLRRSSLEDDYAAAWEDWDRSGEREMWETTASDGLS
Download Length: 219 bp
>AT170253 NZ_CP077236:c4004227-4003976 [Lelliottia amnigena]
ATGAAAATTACCACATCAACCATGCTGGCCAATGCCATGCGAGATCAGCGCAAAGCGCTGGAACTGACTCAAGCAGAAGC
CGCCGAACGCGTGGGGATGAAGCAAACCACGGTATCAGGCTTTGAACAAAATCCGGATACCAGCAAGCTGGAAACGCTAT
TTCGTCTGCTTTCAGCACTGGATTTAGAACTGCACGTTGTGCCCCGGGGCCAGGCGTCAGAAAAGGACAGCGGCTGGACG
CAGGAGTGGTAA
ATGAAAATTACCACATCAACCATGCTGGCCAATGCCATGCGAGATCAGCGCAAAGCGCTGGAACTGACTCAAGCAGAAGC
CGCCGAACGCGTGGGGATGAAGCAAACCACGGTATCAGGCTTTGAACAAAATCCGGATACCAGCAAGCTGGAAACGCTAT
TTCGTCTGCTTTCAGCACTGGATTTAGAACTGCACGTTGTGCCCCGGGGCCAGGCGTCAGAAAAGGACAGCGGCTGGACG
CAGGAGTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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