Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4384779..4385344 Replicon chromosome
Accession NZ_CP060298
Organism Nakamurella sp. PAMC28650

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H7F38_RS19830 Protein ID WP_187094836.1
Coordinates 4384779..4385129 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H7F38_RS19835 Protein ID WP_090480857.1
Coordinates 4385126..4385344 (-) Length 73 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F38_RS19810 4380319..4380726 - 408 WP_187091423.1 ester cyclase -
H7F38_RS19815 4380958..4381620 + 663 WP_187091424.1 TetR/AcrR family transcriptional regulator -
H7F38_RS19820 4382504..4383355 + 852 WP_187091425.1 GAF and ANTAR domain-containing protein -
H7F38_RS19825 4383807..4384589 + 783 WP_187091426.1 alpha/beta fold hydrolase -
H7F38_RS19830 4384779..4385129 - 351 WP_187094836.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H7F38_RS19835 4385126..4385344 - 219 WP_090480857.1 ribbon-helix-helix domain-containing protein Antitoxin
H7F38_RS19840 4386030..4387001 - 972 WP_187091427.1 IS1595 family transposase -
H7F38_RS19855 4388514..4389713 - 1200 WP_187091428.1 site-specific integrase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-113)

Antitoxin

(3-38)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12473.44 Da        Isoelectric Point: 11.1777

>T170253 WP_187094836.1 NZ_CP060298:c4385129-4384779 [Nakamurella sp. PAMC28650]
MMRRGEIRLVDLDPVRGSEANKQRPAVVVSNDRANSVAQRLGRGVVTVVPLTSNTARVFPFQVLIPADAVGLRVASKAQA
EQVRSVAVERVGPSLGLLQASLLAEIDDALRLHLDL

Download         Length: 351 bp

>T170253 NZ_CP077236:c4003975-4002668 [Lelliottia amnigena]
ATGAAAACCAGTAAGCTGACCGTTGCGATGAACGGTACGGTTGTCGGCACGCTGTATCGTAATGGAAAAGGGGCAATGTC
CTGGCAATATGCGCAGACATGGCTCGACACGCCGGGCGCGCGCGTGATTTCACAGTCGCTACCGTTAACGCCGCGTCGTC
AGGAAGGCGAGGTGGTGTATAACTTCTTTAGTAATTTGCTGCCTGACTCGCAGGCGATTATCTCGCGTATGCAAACGCGC
TTTAAAATCCCCACGGATCATCCCTTCGATTTGCTGGCAAGCGTTGGCCGCGACTGTGTTGGGGCAATCCAGCTCTACCC
GGAAAACAGTGAAATACCCCCTGTGACGCACATGCAGGCCACGCCGCTTTCCGATAACGAGATTGCGGCACTGCTGGAAG
GGTATCGTAATGCGCCATTGGGGATGAATGACGACCAGGATTTCAGGATTTCCATTGCAGGTGCGCAGGAAAAAACGGCA
CTGCTCTGGCATCAGAACCGCTGGCAACGCCCCAACGGCAGCACGCCCACCAGCCATATTTTCAAACTGCCCATCGGTAA
AATTGAGCAGAACAATATCGATCTGAGTGAAAGCTGCGAGAACGAATGGCTGTGTCTGCGCCTTGCCCGTGAATTCGGTT
TTTCGGTCGCCGAGGCAACGTTAGCAACCTATGCCGACAAAAAAGTGCTGATTGTTGAGCGTTTTGATCGTAAATGGTCA
CGAGACGGAAAGTGGCTGATGCGACTCCCGCAAGAAGATATGTGTCAGGCTCTCGGGTATTCACCGGCGCTGAAATATGA
ATCTCACGGCGGCCCCGGCATCGCCGAAATCATGACCTTGCTGTTGGGATCGCGCCGCTCAAACCAGGATCGCGAAACGT
TTTTCCGCACTCAGATATTTTACTGGCTGACAGGCGCGATCGATGGCCACGCAAAAAATTACAGTGTGTTTATCGAACCC
GATTCGGCGTACGTTATGACGCCGCTATACGATATTTTGTCAGCCTATCCGGTCTTCGGGCCAAAAGGAATTTCCGCACA
AAAAGCGAAAATGGCCATGGCGTTGCAGGGCAAAAACCGGCAATACCACTGGGCTCAGATTCAACCACGCCATTTCCCGG
CTACGGCTGAACGCGTTGGTTTTTCAGCTATACGCGCAAAAAAGATGATGATCGAAATGGGAAATGCGACAAATGAGATT
ATCGAGCGGGTACGTCAGTCGTTACCGATTGATTTCCCGACACATATCAGCGAAGCGATTTTTAACGGGATGGCGAAGCA
AGCTGAAAGGCTAATACGTTTAGAATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8043.81 Da        Isoelectric Point: 4.4406

>AT170253 WP_090480857.1 NZ_CP060298:c4385344-4385126 [Nakamurella sp. PAMC28650]
MKLSVSLPDDDVAVLDEHARRAGLGSRSAALHQAIRLLRRSSLEDDYAAAWEDWDRSGEREMWETTASDGLS

Download         Length: 219 bp

>AT170253 NZ_CP077236:c4004227-4003976 [Lelliottia amnigena]
ATGAAAATTACCACATCAACCATGCTGGCCAATGCCATGCGAGATCAGCGCAAAGCGCTGGAACTGACTCAAGCAGAAGC
CGCCGAACGCGTGGGGATGAAGCAAACCACGGTATCAGGCTTTGAACAAAATCCGGATACCAGCAAGCTGGAAACGCTAT
TTCGTCTGCTTTCAGCACTGGATTTAGAACTGCACGTTGTGCCCCGGGGCCAGGCGTCAGAAAAGGACAGCGGCTGGACG
CAGGAGTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References