Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2610506..2611167 Replicon chromosome
Accession NZ_CP060298
Organism Nakamurella sp. PAMC28650

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H7F38_RS11875 Protein ID WP_187094237.1
Coordinates 2610760..2611167 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H7F38_RS11870 Protein ID WP_187094236.1
Coordinates 2610506..2610763 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F38_RS11850 2606590..2607855 + 1266 WP_187094232.1 TIGR02679 family protein -
H7F38_RS11855 2607934..2608167 + 234 WP_187094233.1 hypothetical protein -
H7F38_RS11860 2608193..2609464 - 1272 WP_187094234.1 multidrug effflux MFS transporter -
H7F38_RS11865 2609591..2610472 + 882 WP_187094235.1 ABC transporter substrate-binding protein -
H7F38_RS11870 2610506..2610763 + 258 WP_187094236.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H7F38_RS11875 2610760..2611167 + 408 WP_187094237.1 type II toxin-antitoxin system VapC family toxin Toxin
H7F38_RS11880 2611228..2611893 + 666 WP_187094238.1 pyroglutamyl-peptidase I -
H7F38_RS11885 2612057..2612728 - 672 WP_187094239.1 methyltransferase domain-containing protein -
H7F38_RS11890 2612716..2612913 + 198 WP_187094240.1 hypothetical protein -
H7F38_RS11895 2612966..2613562 + 597 WP_187094241.1 XRE family transcriptional regulator -
H7F38_RS11900 2614400..2615365 + 966 WP_187094242.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-44)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14284.42 Da        Isoelectric Point: 4.4237

>T170252 WP_187094237.1 NZ_CP060298:2610760-2611167 [Nakamurella sp. PAMC28650]
VTGRAPSGLLDTSVLIAEESGRRLQVEALPDNAFVSVVTIAELQAGVLAARDTAVRAIRLATLDAVSVLQPLTIDATAAL
HWAVLRVRLAEEGRRAKINDLWIAAVALANDLPVVTQDEDFDSIEAVGGPLVIRV

Download         Length: 408 bp

>T170252 NZ_CP077236:c2830478-2830260 [Lelliottia amnigena]
ATGTCTGATAAACCATTAACTAAGACAGATTATTTGATGCGTTTGCGTCGCTGTCAGTCACTCGACACGCTTGAACGTGT
TATTGAAAAAAATAAATATGAGCTGCCCGATCATGAACTGGCTGTATTTTATTCAGCCGCAGATCATCGTCTTGCCGAGC
TAACCATGAATAAACTGTATGACAAAATCCCGGTGTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9116.28 Da        Isoelectric Point: 6.4633

>AT170252 WP_187094236.1 NZ_CP060298:2610506-2610763 [Nakamurella sp. PAMC28650]
MSTVASRDLRNHTAEVLRRVAAGDRVTITVNGAPVAELIPPSSSRRPSISREGLVLLITRHRADAGLRTDLDALTGETTD
DLEAL

Download         Length: 258 bp

>AT170252 NZ_CP077236:c2830880-2830506 [Lelliottia amnigena]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTCGC
CAATCTTGATGAAAGCAACCATGGCTGGGTTAATGATCCGACCTCTGCAATCAACTTACAGCTTAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGCATTAACACGCAAGACTTGCAAAAATGGCGTAAATCAGGAAATCGGCT
ATTCCGTTGTTTCAACAACGTCAGCAGAGCTAATCCGGTAAGTCATTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References