Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 2065414..2066026 Replicon chromosome
Accession NZ_CP060298
Organism Nakamurella sp. PAMC28650

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H7F38_RS09400 Protein ID WP_187093835.1
Coordinates 2065640..2066026 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H7F38_RS09395 Protein ID WP_187093834.1
Coordinates 2065414..2065647 (+) Length 78 a.a.

Genomic Context

H7F38_RS09370H7F38_RS09375H7F38_RS09390H7F38_RS09395H7F38_RS09400H7F38_RS09365H7F38_RS09380H7F38_RS09385H7F38_RS09405H7F38_RS09410H7F38_RS09415
Location: 2061862..2062122 (261 bp)
Type: Others
Protein ID: WP_187093829.1
Location: 2062472..2062768 (297 bp)
Type: Others
Protein ID: WP_187093830.1
Location: 2064410..2065159 (750 bp)
Type: Others
Protein ID: WP_187093833.1
Location: 2065414..2065647 (234 bp)
Type: Antitoxin
Protein ID: WP_187093834.1
Location: 2065640..2066026 (387 bp)
Type: Toxin
Protein ID: WP_187093835.1
Location: 2060825..2061796 (972 bp)
Type: Others
Protein ID: WP_187091336.1
Location: 2062778..2063074 (297 bp)
Type: Others
Protein ID: WP_187093831.1
Location: 2063498..2064112 (615 bp)
Type: Others
Protein ID: WP_187093832.1
Location: 2066191..2067567 (1377 bp)
Type: Others
Protein ID: WP_187093836.1
Location: 2067634..2069901 (2268 bp)
Type: Others
Protein ID: WP_187093837.1
Location: 2070450..2070941 (492 bp)
Type: Others
Protein ID: WP_187093838.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H7F38_RS093652060825..2061796-972WP_187091336.1IS1595 family transposase-
H7F38_RS093702061862..2062122+261WP_187093829.1hypothetical protein-
H7F38_RS093752062472..2062768+297WP_187093830.1hypothetical protein-
H7F38_RS093802062778..2063074-297WP_187093831.1hypothetical protein-
H7F38_RS093852063498..2064112-615WP_187093832.1hypothetical protein-
H7F38_RS093902064410..2065159+750WP_187093833.1PadR family transcriptional regulator-
H7F38_RS093952065414..2065647+234WP_187093834.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
H7F38_RS094002065640..2066026+387WP_187093835.1type II toxin-antitoxin system VapC family toxinToxin
H7F38_RS094052066191..2067567-1377WP_187093836.1hypothetical protein-
H7F38_RS094102067634..2069901-2268WP_187093837.1hypothetical protein-
H7F38_RS094152070450..2070941-492WP_187093838.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(5-119)

Antitoxin

Post-segregation antitoxin CcdA

(3-46)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13906.10 Da        Isoelectric Point: 6.7608

>T170251 WP_187093835.1 NZ_CP060298:2065640-2066026 [Nakamurella sp. PAMC28650]
MAEVVVDASAMVDLLLDNELGSAVRLRLAGHALHAPAHLDAEVLSALGRLHRAGDLEAEAVESKLRDLVAAPIQRHGVGE
LVIGAWSRRHQLRLVDALYVQLAIVRDLRLVTTDRRLRAMPSADVVTT

Download         Length: 387 bp

>T170251 NZ_CP077236:c2115320-2115003 [Lelliottia amnigena]
ATGAAGGAGATTGTTCAAACAGAATCCTTCCGTTGCTGGGAGCAAAACGTAAACGATCCACGTGCAAAAACGCTTATTGC
AGCGCGTTTATTCCGCCTGGCTAATGGTCTGCCGGGGGATGTAAAACCTGTTGGAGAAGGTATCAGCGAGCTACGGATTC
ATTACGGCCCGGGTTACAGGATCTATTTTAAATCGCAGGGAAACGTACTGATCATTTTGCTCAGTGGCGGCAATAAAAAT
AGTCAGGATAAAGACATCATTCTGGCAAAGACACTCGCAAGATCACTCGAACATCGGGAGTTTATACACCATGACTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8326.25 Da        Isoelectric Point: 5.6643

>AT170251 WP_187093834.1 NZ_CP060298:2065414-2065647 [Nakamurella sp. PAMC28650]
VTRLNVYLPDELAAEAKKAGLNLSAVTQEAVRRTLAERTTDAWLATVATTSSTERVPHDRALDALDAARDEAPTRHG

Download         Length: 234 bp

>AT170251 NZ_CP077236:c2115010-2114723 [Lelliottia amnigena]
ATGACTGAACTCACTCATTACGATCCTGCCCGGGCGCTTATCAATGATGATGAAATTAGCGTATTCATGGCTGATGCGCT
AGAAACTGGCGATTCTGCCTACATTGCTAAAGCATTAGGGATCGTTGCCCGCGCAAAAGGAATGTCTACCATTGCGACAC
AAACGGGTTTGTCTCGCGAACAGCTGTATCGCTCTTTTAGTGAAAAAGGTAACCCAACGCTTAAAACCACGCTTGCCGTT
ATGAAAGCGCTGGGTCTTGGATTGACGATTAAAAGTGCTGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References