Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 2065414..2066026 Replicon chromosome
Accession NZ_CP060298
Organism Nakamurella sp. PAMC28650

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H7F38_RS09400 Protein ID WP_187093835.1
Coordinates 2065640..2066026 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H7F38_RS09395 Protein ID WP_187093834.1
Coordinates 2065414..2065647 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F38_RS09365 2060825..2061796 - 972 WP_187091336.1 IS1595 family transposase -
H7F38_RS09370 2061862..2062122 + 261 WP_187093829.1 hypothetical protein -
H7F38_RS09375 2062472..2062768 + 297 WP_187093830.1 hypothetical protein -
H7F38_RS09380 2062778..2063074 - 297 WP_187093831.1 hypothetical protein -
H7F38_RS09385 2063498..2064112 - 615 WP_187093832.1 hypothetical protein -
H7F38_RS09390 2064410..2065159 + 750 WP_187093833.1 PadR family transcriptional regulator -
H7F38_RS09395 2065414..2065647 + 234 WP_187093834.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H7F38_RS09400 2065640..2066026 + 387 WP_187093835.1 type II toxin-antitoxin system VapC family toxin Toxin
H7F38_RS09405 2066191..2067567 - 1377 WP_187093836.1 hypothetical protein -
H7F38_RS09410 2067634..2069901 - 2268 WP_187093837.1 hypothetical protein -
H7F38_RS09415 2070450..2070941 - 492 WP_187093838.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(5-119)

Antitoxin

Post-segregation antitoxin CcdA

(3-46)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13906.10 Da        Isoelectric Point: 6.7608

>T170251 WP_187093835.1 NZ_CP060298:2065640-2066026 [Nakamurella sp. PAMC28650]
MAEVVVDASAMVDLLLDNELGSAVRLRLAGHALHAPAHLDAEVLSALGRLHRAGDLEAEAVESKLRDLVAAPIQRHGVGE
LVIGAWSRRHQLRLVDALYVQLAIVRDLRLVTTDRRLRAMPSADVVTT

Download         Length: 387 bp

>T170251 NZ_CP077236:c2115320-2115003 [Lelliottia amnigena]
ATGAAGGAGATTGTTCAAACAGAATCCTTCCGTTGCTGGGAGCAAAACGTAAACGATCCACGTGCAAAAACGCTTATTGC
AGCGCGTTTATTCCGCCTGGCTAATGGTCTGCCGGGGGATGTAAAACCTGTTGGAGAAGGTATCAGCGAGCTACGGATTC
ATTACGGCCCGGGTTACAGGATCTATTTTAAATCGCAGGGAAACGTACTGATCATTTTGCTCAGTGGCGGCAATAAAAAT
AGTCAGGATAAAGACATCATTCTGGCAAAGACACTCGCAAGATCACTCGAACATCGGGAGTTTATACACCATGACTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8326.25 Da        Isoelectric Point: 5.6643

>AT170251 WP_187093834.1 NZ_CP060298:2065414-2065647 [Nakamurella sp. PAMC28650]
VTRLNVYLPDELAAEAKKAGLNLSAVTQEAVRRTLAERTTDAWLATVATTSSTERVPHDRALDALDAARDEAPTRHG

Download         Length: 234 bp

>AT170251 NZ_CP077236:c2115010-2114723 [Lelliottia amnigena]
ATGACTGAACTCACTCATTACGATCCTGCCCGGGCGCTTATCAATGATGATGAAATTAGCGTATTCATGGCTGATGCGCT
AGAAACTGGCGATTCTGCCTACATTGCTAAAGCATTAGGGATCGTTGCCCGCGCAAAAGGAATGTCTACCATTGCGACAC
AAACGGGTTTGTCTCGCGAACAGCTGTATCGCTCTTTTAGTGAAAAAGGTAACCCAACGCTTAAAACCACGCTTGCCGTT
ATGAAAGCGCTGGGTCTTGGATTGACGATTAAAAGTGCTGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References