Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 738360..738961 Replicon chromosome
Accession NZ_CP060296
Organism Variovorax sp. PAMC28562

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H7F36_RS03580 Protein ID WP_187053381.1
Coordinates 738659..738961 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H7F36_RS03575 Protein ID WP_187053380.1
Coordinates 738360..738662 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F36_RS03555 733575..735758 + 2184 WP_187053376.1 malate synthase G -
H7F36_RS03560 735948..736535 + 588 WP_187053377.1 fasciclin domain-containing protein -
H7F36_RS03565 736646..737737 + 1092 WP_187053378.1 sensor histidine kinase -
H7F36_RS03570 737734..738363 + 630 WP_187053379.1 response regulator transcription factor -
H7F36_RS03575 738360..738662 - 303 WP_187053380.1 putative addiction module antidote protein Antitoxin
H7F36_RS03580 738659..738961 - 303 WP_187053381.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7F36_RS03585 739011..739769 - 759 WP_187053382.1 flagellar biosynthetic protein FliR -
H7F36_RS03590 739771..740040 - 270 WP_187053383.1 flagellar biosynthesis protein FliQ -
H7F36_RS03595 740063..740842 - 780 WP_187053384.1 flagellar type III secretion system pore protein FliP -
H7F36_RS03600 740835..741131 - 297 WP_187053385.1 flagellar biosynthetic protein FliO -
H7F36_RS03605 741154..741528 - 375 WP_187053386.1 flagellar motor switch protein FliN -
H7F36_RS03610 741518..742513 - 996 WP_187053387.1 flagellar motor switch protein FliM -
H7F36_RS03615 742562..743089 - 528 WP_187054786.1 flagellar basal body-associated FliL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11482.19 Da        Isoelectric Point: 10.2321

>T170249 WP_187053381.1 NZ_CP060296:c738961-738659 [Variovorax sp. PAMC28562]
MIEVRQTPEYEKWFASLKDRTSRARVDIRIRRLSLGNLGSVEPVGEGVSELKIDYGPGYRVYLVQHRGHYVLLLVGGDKS
TQARDIKKAKQLARHYAEQI

Download         Length: 303 bp

>T170249 NZ_CP077236:c1756710-1756336 [Lelliottia amnigena]
ATGGCGAAAGGGTCTGCTCTTTTTGACACCAATATTCTCATCGACTTGTTCAGTGGAAGGGCAGAGGCAAAGCACGCATT
AGAGAGTTGGCCGCCGCAAAATGCGATTAGCATCATCACCTGGATGGAAGTCATGGTGGGAGCAAAAAAATACCATCAGG
AGCATCGTACCCGGATTGCCTTAAGTGCGTTTAACGTCCTTGGTGTTTCACAAGAGGTTGCTGAGCGGAGTGTTGATCTC
CGGCAGGAGTATCGAATGAAGCTCCCGGATGCCATTATTCTGGCTACTGCACAAATTCATCGTCTTGAACTGGTTACGCG
TAATACCAAGGATTTCGGTAACATCCCTGATGTGGTCACGCCCTACAATTTGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10530.03 Da        Isoelectric Point: 5.1023

>AT170249 WP_187053380.1 NZ_CP060296:c738662-738360 [Variovorax sp. PAMC28562]
MTKTTRIWDPAEHLQTDEEMAAYLEAALEEGDASLVAAALGDIARSKGMSQLARETGLGRESLYKALSPSGNPEFATILR
VVGALGIRLHAVPVGAKPVA

Download         Length: 303 bp

>AT170249 NZ_CP077236:c1756952-1756710 [Lelliottia amnigena]
ATGATGGCGGGAAGGGACATGGGCAGAATTCTACTCGATCTATCAGACGAGGTGATAAAACGGCTGGACGACCTCAAGGT
GCACCGGAACGTCCCTCGCGCTGAATTGTTGCGGGAAGCCGTTGAGCAATATCTTGAAAGACACGATCAGGCTGAAAGCA
CGATCTCAGATGCCCTTGGCCTGTGGCATGGCTGTGAGGAAGAGGGTGTTGATTATCAGCGCAAGCTTCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References