Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1497435..1498071 Replicon chromosome
Accession NZ_CP060290
Organism Bacillus sp. PAMC22265

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag H7F24_RS07445 Protein ID WP_024425388.1
Coordinates 1497721..1498071 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag H7F24_RS07440 Protein ID WP_003214273.1
Coordinates 1497435..1497716 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F24_RS07420 1493581..1494186 - 606 WP_103132679.1 rhomboid family intramembrane serine protease -
H7F24_RS07425 1494281..1494646 + 366 WP_041089202.1 holo-ACP synthase -
H7F24_RS07430 1494807..1495823 + 1017 WP_087975235.1 outer membrane lipoprotein carrier protein LolA -
H7F24_RS07435 1495965..1497140 + 1176 WP_103132680.1 alanine racemase -
H7F24_RS07440 1497435..1497716 + 282 WP_003214273.1 hypothetical protein Antitoxin
H7F24_RS07445 1497721..1498071 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
H7F24_RS07450 1498188..1499018 + 831 WP_044334717.1 RsbT co-antagonist protein RsbRA -
H7F24_RS07455 1499023..1499391 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
H7F24_RS07460 1499394..1499795 + 402 WP_073203956.1 anti-sigma regulatory factor -
H7F24_RS07465 1499806..1500813 + 1008 WP_024425391.1 PP2C family protein-serine/threonine phosphatase -
H7F24_RS07470 1500873..1501202 + 330 WP_024425392.1 anti-sigma factor antagonist -
H7F24_RS07475 1501199..1501687 + 489 WP_024425393.1 anti-sigma B factor RsbW -
H7F24_RS07480 1501653..1502441 + 789 WP_024425394.1 RNA polymerase sigma factor SigB -
H7F24_RS07485 1502441..1503040 + 600 WP_024425395.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T170244 WP_024425388.1 NZ_CP060290:1497721-1498071 [Bacillus sp. PAMC22265]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T170244 NZ_CP077233:18135-18491 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT170244 WP_003214273.1 NZ_CP060290:1497435-1497716 [Bacillus sp. PAMC22265]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT170244 NZ_CP077233:18484-18786 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References