Detailed information of TA system TA170240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2088465..2089084
• Replicon: chromosome
• Accession: NZ_CP060289
• Organism: Pseudomonas protegens strain H1F10A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2J7U9Z9
• Locus tag: GGD92_RS09095
• Protein ID: WP_041120604.1
• Coordinates: 2088465..2088647 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GGD92_RS09100
• Protein ID: WP_179597148.1
• Coordinates: 2088683..2089084 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GGD92_RS09070	2084021..2085259	-	1239	WP_179597144.1	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	-
GGD92_RS09075	2085280..2085798	-	519	WP_080966932.1	sugar O-acetyltransferase	-
GGD92_RS09080	2086334..2086908	+	575	Protein_1810	hypothetical protein	-
GGD92_RS09085	2087062..2087580	+	519	WP_179597146.1	hypothetical protein	-
GGD92_RS09090	2087666..2087872	+	207	Protein_1812	hypothetical protein	-
GGD92_RS09095	2088465..2088647	+	183	WP_041120604.1	type II toxin-antitoxin system HicA family toxin	Toxin
GGD92_RS09100	2088683..2089084	+	402	WP_179597148.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GGD92_RS09105	2089242..2090645	-	1404	WP_179597150.1	PLP-dependent aminotransferase family protein	-
GGD92_RS09110	2090733..2091179	+	447	WP_179597152.1	GNAT family N-acetyltransferase	-
GGD92_RS09115	2091176..2091796	+	621	WP_179597154.1	NAD(P)H-dependent oxidoreductase	-
GGD92_RS09120	2091824..2092255	+	432	WP_179597156.1	carboxymuconolactone decarboxylase family protein	-
GGD92_RS09125	2092829..2092951	-	123	Protein_1819	PAAR domain-containing protein	-
GGD92_RS09130	2093005..2093436	-	432	WP_179597158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2071221..2095049	23828

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6885.09 Da
• Isoelectric Point: 11.2684

>T170240 WP_041120604.1 NZ_CP060289:2088465-2088647 [Pseudomonas protegens]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPNTVPVPHPKKDLPRGTVRAIRKLAELI

Nucleotide

• Length: 183 bp

>T170240 NZ_CP077232:c421998-421696 [Acinetobacter pittii]
ATGTATGAAATCAAAACTACCGAGACTTTTGACGAATGGTTTGATTCGTTAAGAGACACTCAAGGCAAGGCGCGTATTAA
TGCTCGTTTGCGTCGGGTTGAACTTGGTAATTTCGGAGACGCCGAGCCTGTTGGTGAAAATGTATCTGAACTAAGATTCT
TTTTTGGCCCCGGATATAGAGTTTACTTCATACAGGAAGGTGATGAGATCATTGTCTTACTAGCTGGTGGTGATAAATCT
TCACAGCAAAAAGATATTGATAAGGCTATTGAATTAGCAAAAGAAATTCGAGGTGAGTCATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14644.66 Da
• Isoelectric Point: 5.1754

>AT170240 WP_179597148.1 NZ_CP060289:2088683-2089084 [Pseudomonas protegens]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDSFESAYSAAIEIAHVMLEELARAGHAIPLPSPTRKHRANPDFEGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAAMEKLGR

Nucleotide

• Length: 402 bp

>AT170240 NZ_CP077232:c421699-421409 [Acinetobacter pittii]
ATGACTGTTAAGTTGAAAAAATGGAACATCCAAGATCATCTTAAAACAGAAGAAGAGCGCCAAGCTTATTTAGAAGCGGC
ACTAGAGGAAGCTAGTGATGATCCTTTATACATTGCTCATGTCTTAGGCGACATAGCTAAATCATATGGAATGACTAAGC
TTGCGCAAGAAACAGGGTTAACTCGTGAAGGTTTATACAAATCCTTTGGCAAACAAGGCAATCCTAGCTTTGTAACTGTT
AGTAAAGTAGCAGGTGCTATGGGATTAAAGTTAACTTTTGAACATGCATAA

Structures

Toxin

• AlphaFold DB: A0A2J7U9Z9