Detailed information of TA system TA170239

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1623215..1623845
• Replicon: chromosome
• Accession: NZ_CP060289
• Organism: Pseudomonas protegens strain H1F10A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GGD92_RS06940
• Protein ID: WP_092315415.1
• Coordinates: 1623215..1623394 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GGD92_RS06945
• Protein ID: WP_102864418.1
• Coordinates: 1623438..1623845 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GGD92_RS06930	1620514..1621680	+	1167	WP_179596661.1	efflux RND transporter periplasmic adaptor subunit	-
GGD92_RS06935	1621664..1623085	+	1422	WP_179596664.1	efflux transporter outer membrane subunit	-
GGD92_RS06940	1623215..1623394	+	180	WP_092315415.1	type II toxin-antitoxin system HicA family toxin	Toxin
GGD92_RS06945	1623438..1623845	+	408	WP_102864418.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GGD92_RS06950	1625242..1625514	+	273	WP_179596666.1	hypothetical protein	-
GGD92_RS06955	1625714..1626163	-	450	WP_179596668.1	peptide-methionine (S)-S-oxide reductase MsrA	-
GGD92_RS06960	1626160..1627215	-	1056	WP_179596671.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6659.84 Da
• Isoelectric Point: 11.1799

>T170239 WP_092315415.1 NZ_CP060289:1623215-1623394 [Pseudomonas protegens]
VNSRQLIAQIEADGWYLVRVKGSHHHFKHPTKPGLVTIPHPKKDLLAKTVSSILKQARL

Nucleotide

• Length: 180 bp

>T170239 NZ_CP077232:c421699-421409 [Acinetobacter pittii]
ATGACTGTTAAGTTGAAAAAATGGAACATCCAAGATCATCTTAAAACAGAAGAAGAGCGCCAAGCTTATTTAGAAGCGGC
ACTAGAGGAAGCTAGTGATGATCCTTTATACATTGCTCATGTCTTAGGCGACATAGCTAAATCATATGGAATGACTAAGC
TTGCGCAAGAAACAGGGTTAACTCGTGAAGGTTTATACAAATCCTTTGGCAAACAAGGCAATCCTAGCTTTGTAACTGTT
AGTAAAGTAGCAGGTGCTATGGGATTAAAGTTAACTTTTGAACATGCATAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14752.81 Da
• Isoelectric Point: 4.5801

>AT170239 WP_102864418.1 NZ_CP060289:1623438-1623845 [Pseudomonas protegens]
MLYPIAILPGDDQHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHLELLAEEGAAIPTARTVTLHAANPQYQGCTWAV
IDIDITRYMGKAEKLNITLPGYLLNRIDEYVKHHPEQKSRSGFLAQAALRVLQGV

Nucleotide

• Length: 408 bp

>AT170239 NZ_CP077232:c421998-421696 [Acinetobacter pittii]
ATGTATGAAATCAAAACTACCGAGACTTTTGACGAATGGTTTGATTCGTTAAGAGACACTCAAGGCAAGGCGCGTATTAA
TGCTCGTTTGCGTCGGGTTGAACTTGGTAATTTCGGAGACGCCGAGCCTGTTGGTGAAAATGTATCTGAACTAAGATTCT
TTTTTGGCCCCGGATATAGAGTTTACTTCATACAGGAAGGTGATGAGATCATTGTCTTACTAGCTGGTGGTGATAAATCT
TCACAGCAAAAAGATATTGATAAGGCTATTGAATTAGCAAAAGAAATTCGAGGTGAGTCATGA