Detailed information of TA system TA170233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 3340088..3340641
• Replicon: chromosome
• Accession: NZ_CP060286
• Organism: Caproiciproducens sp. 7D4C2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HCR03_RS16595
• Protein ID: WP_187035499.1
• Coordinates: 3340088..3340369 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HCR03_RS16600
• Protein ID: WP_187035502.1
• Coordinates: 3340366..3340641 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCR03_RS16570	3335605..3336711	+	1107	WP_187035491.1	hypothetical protein	-
HCR03_RS16575	3337203..3337628	+	426	WP_187035493.1	sigma-70 family RNA polymerase sigma factor	-
HCR03_RS16580	3337718..3338149	+	432	WP_187035495.1	sigma-70 family RNA polymerase sigma factor	-
HCR03_RS16585	3338158..3338373	+	216	WP_207727254.1	DUF3847 domain-containing protein	-
HCR03_RS16590	3338591..3340025	+	1435	Protein_3257	MobA/MobL family protein	-
HCR03_RS16595	3340088..3340369	-	282	WP_187035499.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HCR03_RS16600	3340366..3340641	-	276	WP_187035502.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HCR03_RS16605	3341170..3341370	+	201	WP_187035505.1	transposon-encoded TnpW family protein	-
HCR03_RS16610	3341606..3345238	+	3633	WP_187035507.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3281367..3355602	74235

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-88)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10847.62 Da
• Isoelectric Point: 9.0534

>T170233 WP_187035499.1 NZ_CP060286:c3340369-3340088 [Caproiciproducens sp. 7D4C2]
MKLDIVWTSQFKKDYKLAVKRGLKMDLLDNIIRQLSKCQPLPEKNRDHLLTGNYVGYRECHIQSDWLLVYRIENGVLVLT
LARTGSHSDLFGE

Nucleotide

• Length: 282 bp

>T170233 NZ_CP077211:5150514-5150732 [Enterobacter cloacae]
ATGTCTGATAAACCACTCACAAAAACCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACACTCGAACGCGT
GATTGAAAAAAATAAATACGAGCTTTCTGATAATGAACTGACCGTATTTTATTCAGCCGCTGACCATCGCCTTGCCGAGC
TGACCATGAATAAACTGTATGACAAAATCCCTCCTTCCGTGTGGAAATTTGTCCGTTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10214.61 Da
• Isoelectric Point: 6.2986

>AT170233 WP_187035502.1 NZ_CP060286:c3340641-3340366 [Caproiciproducens sp. 7D4C2]
MANTTNFSVRMDSDIKKQCEALYSELGMNLTTAINVFLRQSLRSGGFPFDVTLNTPNAVTLAAMQEAERLAKDPNAKRYS
DVEEALRELKR

Nucleotide

• Length: 276 bp

>AT170233 NZ_CP077211:5150112-5150486 [Enterobacter cloacae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAATCATGGCTGGGTGAACGATCCAACATCGGCCATCAATTTGCAATTGAATGAGTTGATAGAGC
ATATCGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAACTGATTGAGCAAATTGACGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCGCAGGATTTGCAGAAATGGCGTAAATCTGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA