Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1181551..1182202 Replicon chromosome
Accession NZ_CP060285
Organism Acinetobacter baumannii strain XYAB2018

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag H7X63_RS05635 Protein ID WP_000838146.1
Coordinates 1181551..1181733 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag H7X63_RS05640 Protein ID WP_000966689.1
Coordinates 1181798..1182202 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7X63_RS05590 1176808..1177473 + 666 WP_038337351.1 stress-responsive nuclear envelope protein -
H7X63_RS05595 1177478..1177867 + 390 WP_000008492.1 hypothetical protein -
H7X63_RS05600 1177824..1178237 + 414 WP_001197735.1 hypothetical protein -
H7X63_RS05605 1178246..1178650 + 405 WP_000248324.1 hypothetical protein -
H7X63_RS05610 1178622..1178990 + 369 WP_000539752.1 hypothetical protein -
H7X63_RS05615 1178992..1179390 + 399 WP_001132270.1 hypothetical protein -
H7X63_RS05620 1179392..1179604 + 213 WP_000121166.1 hypothetical protein -
H7X63_RS05625 1179712..1180641 + 930 WP_000094300.1 hypothetical protein -
H7X63_RS05630 1180686..1181219 + 534 WP_001185622.1 hypothetical protein -
H7X63_RS05635 1181551..1181733 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
H7X63_RS05640 1181798..1182202 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H7X63_RS05645 1182283..1182684 + 402 WP_000720591.1 hypothetical protein -
H7X63_RS05650 1182745..1186710 + 3966 WP_000191304.1 tape measure protein -
H7X63_RS05655 1186828..1187169 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1154813..1205095 50282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T170232 WP_000838146.1 NZ_CP060285:1181551-1181733 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T170232 NZ_CP077211:5032477-5032839 [Enterobacter cloacae]
ATGTGGAACGTCGAGACAACAGACAGATTTGATGAATGGTTCTTTGAACAAACAACAGCGTTAAAAGAAGATGTGCTGGC
AGCAATGCATATTCTTTCTGAGTTTGGTCCGCAACTTGGGCGGCCGTTTGTAGACACCGTGAAGGCTTCAGCCTTTGGGA
ACATGAAAGAGTTACGAATTCAGCACAGAGGAAATCCCATCAGGGCCTTTTTTGCTTTTGATCCTGACCGCAAAGCAATT
GTGCTCTGTGCCGGGGACAAAACCGGTTGCAACCAAAAACGGTTTTATAAAGAGATGATAGCGCTGGCTGACGTTGAGTA
TCACAGACATCTGGCGAATAAGGAGGCCATATGGCAACGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT170232 WP_000966689.1 NZ_CP060285:1181798-1182202 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT170232 NZ_CP077211:5032827-5033126 [Enterobacter cloacae]
ATGGCAACGCTAAAAGAACTTATGGCACAACAGAGCGCGGAAAGTCAGGAGCGCATTGCGGCGAAAGTTGAAGTGATGCG
CAGAATTGTTGCGCTGAACCAACTGCGGGAAGAGCTCAATATTTCGCAGACAGAACTGGCTGCGGCAATGGGGGTAAAAC
AACCCACGGTGGCGAAAATCGAACAGCCGGGAAACGACCCCCGACTTTCAACGCTCAAACGCTATGTGAGTGCGCTTGGA
GGGGAGCTAAGCATCGATGTGACGTTACCAAACGGGAAACGGATAGCGTTTGAGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References