Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 800124..800781 Replicon chromosome
Accession NZ_CP060281
Organism Klebsiella pneumoniae strain ent1077

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag H7U30_RS03940 Protein ID WP_002916310.1
Coordinates 800371..800781 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag H7U30_RS03935 Protein ID WP_002916312.1
Coordinates 800124..800390 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7U30_RS03910 795332..796765 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
H7U30_RS03915 796884..797612 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
H7U30_RS03920 797662..797973 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
H7U30_RS03925 798137..798796 + 660 WP_002916317.1 hemolysin III family protein -
H7U30_RS03930 798895..799878 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
H7U30_RS03935 800124..800390 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
H7U30_RS03940 800371..800781 + 411 WP_002916310.1 protein YgfX Toxin
H7U30_RS03945 800788..801309 - 522 WP_002916308.1 flavodoxin FldB -
H7U30_RS03950 801410..802306 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
H7U30_RS03955 802329..803042 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H7U30_RS03960 803048..804781 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T170213 WP_002916310.1 NZ_CP060281:800371-800781 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T170213 NZ_CP077206:449834-450118 [Enterobacter bugandensis]
ATGATTTATGAACTGGAGTTCGACCCGAGGGCTTTAAAGGAGTGGCATAAGCTGGGCGATACGGTGAAATGCCAGTTTAA
AAAGAAACTTGCTGACGTCTTAGTGAACCCCAGAATTGAATCGGCCCGCCTGCACGGCCTGTCGGATTGCTACAAAATAA
AACTCAGATCTCTGGGTTATCGTTTGGTTTATCAGGTTCAGGATAACGTAGTTACGGTATTTGTTATCGCTATCGGAAAG
AGAGAGAAATCAGCCGTTTATCATGAAGCAAATAAACGGCTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT170213 WP_002916312.1 NZ_CP060281:800124-800390 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT170213 NZ_CP077206:449602-449844 [Enterobacter bugandensis]
ATGGCCACGCTTAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCGTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCCGTGCGGTTACTGTTTCAGTACGTTGCGGAAACAGGGCGTATGCCGGTGAAAACTGTCACCATCAGTGACA
GTGAAGATGAACTGATACAGACAGTCCGGGAGCGACTGGCGAATCCACAAAAGGGAATTAAGGTTAGTCTGGATGATTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References