Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2523807..2524321 Replicon chromosome
Accession NZ_CP060278
Organism Staphylococcus aureus strain KZN

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag H7684_RS12410 Protein ID WP_000581792.1
Coordinates 2523807..2524016 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag H7684_RS12415 Protein ID WP_000138932.1
Coordinates 2524028..2524321 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7684_RS12390 (2519315) 2519315..2520673 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
H7684_RS12395 (2520688) 2520688..2521758 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
H7684_RS12400 (2522076) 2522076..2523278 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
H7684_RS12405 (2523542) 2523542..2523679 - 138 WP_000828354.1 Lmo0850 family protein -
H7684_RS12410 (2523807) 2523807..2524016 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
H7684_RS12415 (2524028) 2524028..2524321 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
H7684_RS12420 (2524487) 2524487..2525971 + 1485 WP_000571549.1 cardiolipin synthase -
H7684_RS12425 (2525999) 2525999..2526646 + 648 WP_001187630.1 HD domain-containing protein -
H7684_RS12430 (2527559) 2527559..2528431 - 873 WP_000725802.1 membrane protein insertase YidC -
H7684_RS12435 (2528517) 2528517..2529158 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T170206 WP_000581792.1 NZ_CP060278:c2524016-2523807 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T170206 NZ_CP077198:590498-590800 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT170206 WP_000138932.1 NZ_CP060278:c2524321-2524028 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT170206 NZ_CP077198:590253-590510 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References