Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1226847..1227324 Replicon chromosome
Accession NZ_CP060278
Organism Staphylococcus aureus strain KZN

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag H7684_RS05790 Protein ID WP_000052076.1
Coordinates 1226847..1227035 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag H7684_RS05795 Protein ID WP_001059690.1
Coordinates 1227064..1227324 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7684_RS05760 (1222841) 1222841..1223362 + 522 WP_000824482.1 hypothetical protein -
H7684_RS05765 (1223703) 1223703..1224389 + 687 WP_000141557.1 thermonuclease family protein -
H7684_RS05770 (1224746) 1224746..1224946 + 201 WP_001059082.1 cold-shock protein -
H7684_RS05775 (1225438) 1225438..1225656 - 219 WP_000005886.1 hypothetical protein -
H7684_RS05780 (1225718) 1225718..1226002 - 285 WP_001004399.1 hypothetical protein -
H7684_RS05785 (1226090) 1226090..1226659 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
H7684_RS05790 (1226847) 1226847..1227035 - 189 WP_000052076.1 hypothetical protein Toxin
H7684_RS05795 (1227064) 1227064..1227324 - 261 WP_001059690.1 hypothetical protein Antitoxin
H7684_RS05800 (1227665) 1227665..1227868 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
H7684_RS05805 (1227865) 1227865..1228101 - 237 WP_000349581.1 hypothetical protein -
H7684_RS05810 (1228326) 1228326..1228907 + 582 WP_001140693.1 histidine phosphatase family protein -
H7684_RS05815 (1228980) 1228980..1229597 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
H7684_RS05820 (1229752) 1229752..1230246 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
H7684_RS05825 (1230645) 1230645..1231067 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
H7684_RS05830 (1231215) 1231215..1231931 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-68)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T170197 WP_000052076.1 NZ_CP060278:c1227035-1226847 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T170197 NZ_CP077198:518302-518589 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT170197 WP_001059690.1 NZ_CP060278:c1227324-1227064 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT170197 NZ_CP077198:518600-518917 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTGAGTAATTTGATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References