Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 62102..62745 Replicon plasmid pCC119
Accession NZ_CP060277
Organism Serratia ureilytica strain CC119

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag D0895_RS24315 Protein ID WP_187048952.1
Coordinates 62329..62745 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag D0895_RS24310 Protein ID WP_187048951.1
Coordinates 62102..62332 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0895_RS24285 58221..59345 + 1125 WP_187049022.1 phage tail protein -
D0895_RS24290 59501..60664 + 1164 WP_187049023.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
D0895_RS24295 60852..61175 + 324 WP_187049024.1 EAL domain-containing protein -
D0895_RS24300 61114..61455 + 342 WP_187049025.1 EAL domain-containing protein -
D0895_RS24305 61374..61853 - 480 Protein_68 hypothetical protein -
D0895_RS24310 62102..62332 + 231 WP_187048951.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D0895_RS24315 62329..62745 + 417 WP_187048952.1 PIN domain-containing protein Toxin
D0895_RS24320 62797..63027 + 231 WP_187048953.1 hypothetical protein -
D0895_RS24325 63256..63951 + 696 WP_187048954.1 SOS response-associated peptidase family protein -
D0895_RS24330 64282..65097 + 816 Protein_73 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
D0895_RS24335 65300..65590 + 291 WP_187048955.1 hypothetical protein -
D0895_RS24340 65789..66031 - 243 WP_070914200.1 hypothetical protein -
D0895_RS24345 66034..66657 - 624 WP_060432385.1 AAA family ATPase -
D0895_RS24350 66829..67572 - 744 WP_025862211.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pilW 1..122584 122584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14986.34 Da        Isoelectric Point: 7.3234

>T170192 WP_187048952.1 NZ_CP060277:62329-62745 [Serratia ureilytica]
VNKIYMLDTNICSFIMREQPEAVIKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPHHAPLVDAFCARLDAILPWDRA
AVDATTEIKAALAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFARVPDLTLEDWVR

Download         Length: 417 bp

>T170192 NZ_CP077098:c2258982-2258773 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8603.72 Da        Isoelectric Point: 4.5881

>AT170192 WP_187048951.1 NZ_CP060277:62102-62332 [Serratia ureilytica]
MRIVSIFKNGNNRAIRLPRDLDFEGVSELEIAREGDSIILRPVRPTWGSFTQLEKADPGFLAERADVVSDEGRFDL

Download         Length: 231 bp

>AT170192 NZ_CP077098:c2259287-2258994 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References