Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4095032..4095701 Replicon chromosome
Accession NZ_CP060276
Organism Serratia ureilytica strain CC119

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B4GZI3
Locus tag D0895_RS19510 Protein ID WP_042785308.1
Coordinates 4095032..4095454 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag D0895_RS19515 Protein ID WP_019455657.1
Coordinates 4095435..4095701 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0895_RS19490 4090959..4092692 - 1734 WP_033639478.1 single-stranded-DNA-specific exonuclease RecJ -
D0895_RS19495 4092699..4093415 - 717 WP_042785306.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
D0895_RS19500 4093442..4094341 - 900 WP_033644935.1 site-specific tyrosine recombinase XerD -
D0895_RS19505 4094448..4094966 + 519 WP_033635825.1 flavodoxin FldB -
D0895_RS19510 4095032..4095454 - 423 WP_042785308.1 protein YgfX Toxin
D0895_RS19515 4095435..4095701 - 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
D0895_RS19520 4096022..4097014 + 993 WP_042785310.1 tRNA-modifying protein YgfZ -
D0895_RS19525 4097053..4097550 - 498 WP_033644774.1 DUF2165 domain-containing protein -
D0895_RS19530 4097701..4098375 - 675 WP_033644772.1 hemolysin III family protein -
D0895_RS19535 4098559..4099167 + 609 WP_047573791.1 HD domain-containing protein -
D0895_RS19540 4099208..4100134 - 927 WP_187048341.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16527.59 Da        Isoelectric Point: 10.8114

>T170188 WP_042785308.1 NZ_CP060276:c4095454-4095032 [Serratia ureilytica]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQD

Download         Length: 423 bp

>T170188 NZ_CP077098:2052932-2053393 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACATGGCTTTATCTCAGCAGTCCCGTTACGTGAAATTGTAGAAGCTTACAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAAAATACATATTAGAAGCAATTAATCACTATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT170188 WP_019455657.1 NZ_CP060276:c4095701-4095435 [Serratia ureilytica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT170188 NZ_CP077098:2052596-2052919 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGAATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References