Detailed information of TA system TA170176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1579623..1580171
• Replicon: chromosome
• Accession: NZ_CP060276
• Organism: Serratia ureilytica strain CC119

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: D0895_RS07610
• Protein ID: WP_028127948.1
• Coordinates: 1579869..1580171 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: D0895_RS07605
• Protein ID: WP_025302143.1
• Coordinates: 1579623..1579859 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0895_RS07590	1576110..1577645	+	1536	WP_042784031.1	glutathione ABC transporter substrate-binding protein GsiB	-
D0895_RS07595	1577698..1578618	+	921	WP_089191398.1	glutathione ABC transporter permease GsiC	-
D0895_RS07600	1578628..1579536	+	909	WP_187048755.1	glutathione ABC transporter permease GsiD	-
D0895_RS07605	1579623..1579859	+	237	WP_025302143.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
D0895_RS07610	1579869..1580171	+	303	WP_028127948.1	CcdB family protein	Toxin
D0895_RS07615	1580207..1581049	-	843	WP_187048756.1	S-formylglutathione hydrolase	-
D0895_RS07620	1581064..1582188	-	1125	WP_016928454.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
D0895_RS07625	1582219..1583139	-	921	WP_164107264.1	LysR family transcriptional regulator	-
D0895_RS07630	1583245..1584402	+	1158	WP_033650593.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-99)

Antitoxin

• Post-segregation antitoxin CcdA (8-78)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11210.98 Da
• Isoelectric Point: 5.0196

>T170176 WP_028127948.1 NZ_CP060276:1579869-1580171 [Serratia ureilytica]
ITVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKAVG
NVNEHRNQIKAAIDFLIDGF

Nucleotide

• Length: 303 bp

>T170176 NZ_CP077095:3200453-3201037 [Pseudomonas xantholysinigenes]
ATGGATCTCGACCTGCTCGCCAGTCGCCTGGCGTTTCTACGCGAGGCCGAACGCCTCAAGGATGTGCTACGCAGTGCCCA
TACCTCATCTGGGCGCACGGAAAGCACAGCAGAGCATAGCTGGCGATTGTCCCTGATGGCGCTGGTGTTCGCCGACCAGA
TGCCAGGTCTTGACCTGCTGAAAGTCATCCAGCTGTGCGTGGTGCACGACCTGGGCGAGGCGTTGCATGGCGATATCCCC
GCCGTCGACCAGGTGCCGGGCCAGCACAAGGACCAGCAGGAGTTCGAAGACCTGCAACAGCTCTGCGCCAGCCTCGACGC
CCCCTTGCGCGCGCAAATCCTGCAACTGTGGCAGGAATATGCCGCGGCCCACAGCGCCGAAGCCAAGACGGTCAAGGCCC
TGGACAAGCTCGAGACCCTGCTGCAGCACACCCAGGGCGCCAACCCCGGCGACTTCGACTATGCCTTCAACCTCGACTAC
GGGCGTCGCTATACTGACGCCGCGCCGCTGTTTCGCGCCTTGCGCGAACAGATCGACAACGACACGCGCCAGCGTATGAC
ACACATTGCCCAGAAGACACCATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8967.04 Da
• Isoelectric Point: 5.0807

>AT170176 WP_025302143.1 NZ_CP060276:1579623-1579859 [Serratia ureilytica]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Nucleotide

• Length: 237 bp

>AT170176 NZ_CP077095:3199808-3200371 [Pseudomonas xantholysinigenes]
ATGCCCACCACTGCCCTGCCCCAGGCCGCCGAGCTGGGTGTCGCGCTACGCCGCTGGCGCCTGTTGCATCGGGTCAAGCA
AGCGCATGCCGCCCAACTGTTCAGCGTGGCGCAGTCGACCATCTCGCGCTGGGAAAACGGCCTGCAGGCCATGAATCCTG
ATGAGCAGGCACGGCTCGGGCAGTTGCTCGGCGCACGCCTGAGCGCGGCGGCCGATCAGGCCCTGGCGCGCCTGGTCGAA
GGCAGCCAGCAGCCGGTGCACCTGGTCTGCGACCTCAGCCATCGCCTGCTGGCCTGTTCGCCCGCCCGCGCCGCCGAGTT
CAGCCTGCCGCTGTCGGCGCTCATGGGCCGCTCGCTGTGGCGGTTCAGCAGCGAGGCGATCATCCAGCGCGAAGCAAGCC
TGCAAGCCTTGGGTTGGCGCGAGCAACTGGCGCCACCGGCGCTGGCGTTCGATACCGGCTGCAATCGCTCGCGGGTGGTC
CCCATCAGCGCCGGGACCTGCCGCTGGACGCGGCTGATCCTCGCCGATGGCAGCGCGGCGCGCCTGGTCGAGACCCTGGC
GTGA