Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1093131..1093753 Replicon chromosome
Accession NZ_CP060276
Organism Serratia ureilytica strain CC119

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag D0895_RS05220 Protein ID WP_004940313.1
Coordinates 1093131..1093334 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag D0895_RS05225 Protein ID WP_004940312.1
Coordinates 1093385..1093753 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0895_RS05195 1088943..1089407 + 465 WP_033651100.1 type II secretion system protein M -
D0895_RS05200 1089423..1090238 + 816 WP_187048670.1 A24 family peptidase -
D0895_RS05205 1090235..1090597 - 363 WP_147838717.1 type II secretion system pilot lipoprotein GspS -
D0895_RS05210 1090851..1092278 + 1428 WP_042783800.1 N-acetylglucosamine-binding protein GbpA -
D0895_RS05215 1092331..1092849 + 519 WP_033651103.1 cytochrome b/b6 domain-containing protein -
D0895_RS05220 1093131..1093334 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
D0895_RS05225 1093385..1093753 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
D0895_RS05230 1093913..1094266 - 354 WP_047572432.1 hypothetical protein -
D0895_RS05235 1094673..1095386 + 714 WP_042783802.1 ABC transporter ATP-binding protein -
D0895_RS05240 1095383..1096240 + 858 WP_042783803.1 metal ABC transporter permease -
D0895_RS05245 1096266..1097144 + 879 WP_042783804.1 zinc ABC transporter substrate-binding protein -
D0895_RS05250 1097250..1097390 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
D0895_RS05255 1097403..1097657 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T170175 WP_004940313.1 NZ_CP060276:c1093334-1093131 [Serratia ureilytica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T170175 NZ_CP077095:c1156454-1156134 [Pseudomonas xantholysinigenes]
ATGCTCTTCACCGAAACGGCCATCTTCACCAAACGCGTCCAGGAACTGCTCGACGATGAGAGCTACCGGTTGCTGCAGGT
CCGTCTGCTGATGTGCCCCGATGCGGGCGATACGATCGAAGGCACCGGTGGCCTGCGCAAGATCCGCATCGCCGCGAAGG
GGCACGGCAAACGGGGTGGCGCCCGGGTGATCTATTACCACTTCGTATCCGCATCGCACATTGCAATGCTCTACATCTAC
CCCAAGAACGAACAACCCGACCTCAATGCCGAGCAACGCAAAGCACTGAAAGCCGTCATCGCACACTGGAGCCAACCATG
A

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT170175 WP_004940312.1 NZ_CP060276:c1093753-1093385 [Serratia ureilytica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT170175 NZ_CP077095:c1156137-1155850 [Pseudomonas xantholysinigenes]
ATGAATCGCCTCTTCGACGAACTGATGGAAAGCGTGGAGCAGATGGACGCCATCGTCCATGGCCGGCGCCAACCCGCCCG
CCAGTTCGAGATCGACGCCCTGCAGGTCAAAAACATCCGCAAGGCGACCGGGTTGTCCCAGACGCGCTTTGCCGAAATGA
TCGATGTTCAGGTAGCGACCCTGCGCAATTGGGAACAGGGGCGCCGGGAGCCTACCGGGCCAGCCAAGGCGTTGCTGCGT
GCCATTCACAACGACCCTGACCACGTGCTCAAGGCACTCGCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References