Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 44988..45589 Replicon chromosome
Accession NZ_CP060276
Organism Serratia ureilytica strain CC119

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag D0895_RS00230 Protein ID WP_025304766.1
Coordinates 44988..45368 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag D0895_RS00235 Protein ID WP_025304767.1
Coordinates 45368..45589 (-) Length 74 a.a.

Genomic Context

D0895_RS00205D0895_RS00215D0895_RS00220D0895_RS00225D0895_RS00245D0895_RS00250D0895_RS00210D0895_RS00230D0895_RS00235D0895_RS00240
Location: 40235..41515 (1281 bp)
Type: Others
Protein ID: WP_033645140.1
Location: 42203..42616 (414 bp)
Type: Others
Protein ID: WP_004933919.1
Location: 42723..43151 (429 bp)
Type: Others
Protein ID: WP_004933922.1
Location: 43319..44977 (1659 bp)
Type: Others
Protein ID: WP_187048490.1
Location: 47927..48706 (780 bp)
Type: Others
Protein ID: WP_033645137.1
Location: 48786..49925 (1140 bp)
Type: Others
Protein ID: WP_033645136.1
Location: 41546..41893 (348 bp)
Type: Others
Protein ID: WP_016929593.1
Location: 44988..45368 (381 bp)
Type: Toxin
Protein ID: WP_025304766.1
Location: 45368..45589 (222 bp)
Type: Antitoxin
Protein ID: WP_025304767.1
Location: 45663..46913 (1251 bp)
Type: Others
Protein ID: WP_047025992.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D0895_RS0020540235..41515+1281WP_033645140.1DUF3748 domain-containing protein-
D0895_RS0021041546..41893-348WP_016929593.1YceK/YidQ family lipoprotein-
D0895_RS0021542203..42616+414WP_004933919.1heat shock chaperone IbpA-
D0895_RS0022042723..43151+429WP_004933922.1heat shock chaperone IbpB-
D0895_RS0022543319..44977+1659WP_187048490.1putative transporter-
D0895_RS0023044988..45368-381WP_025304766.1type II toxin-antitoxin system VapC family toxinToxin
D0895_RS0023545368..45589-222WP_025304767.1ribbon-helix-helix domain-containing proteinAntitoxin
D0895_RS0024045663..46913-1251WP_047025992.1valine--pyruvate transaminase-
D0895_RS0024547927..48706+780WP_033645137.12OG-Fe dioxygenase family protein-
D0895_RS0025048786..49925+1140WP_033645136.1PLP-dependent aspartate aminotransferase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T170173 WP_025304766.1 NZ_CP060276:c45368-44988 [Serratia ureilytica]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T170173 NZ_CP077094:c4961759-4961457 [Pseudomonas promysalinigenes]
ATGAAGAGTATCAAGCAGACAGCCACCTACAGGAATTGGGAGCGCAAGCTACGGGACAAGCAGGCTAGAGCAATTATTGC
TGCACGCGTTTTTCGTCTGGCGCATGGTTTGCTTGGTGATGTCCAGCCAGTGGGTCAAGGTATCAGCGAACTGCGTATCC
ATCATGGACCCGGTTACCGTATCTATTATCAGCAACGCGGTAATCAGTTGGTACTGTTGTTATGTGGTGGGGACAAGAGC
AGCCAGTCGCGAGATATCGAGACAGCGAAATCACTGGCCAGCCAGTGGAGTGATGATGAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT170173 WP_025304767.1 NZ_CP060276:c45589-45368 [Serratia ureilytica]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT170173 NZ_CP077094:c4961460-4961161 [Pseudomonas promysalinigenes]
ATGAAAGAACAGTTTTATGATTACGACCCAGCCGAAGCGCTGACCGATGCAGAGTCCATTGCCATATTCATGGAGGATGC
GTTTGAGACGGGTGACGCGGCGTACATTGCGCAGGCCCTCGGTGTAGTGGCCCGCGCTAAGGGTATGACCACTATTGCCA
CTGAGGCGGGTGTTTCCCGGGAGCATCTGTATCGGTCGTTCTCGGAGAAAGGTAACCCTACGCTCAAGACGATGTTGGCT
GTGATGCGGGCGGTTGGTCTGGACCTGACCTCCCGCAGACACAGCAAACCGGCGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A8B4GSJ7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A8B4GSF3

References