Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 44988..45589 Replicon chromosome
Accession NZ_CP060276
Organism Serratia ureilytica strain CC119

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag D0895_RS00230 Protein ID WP_025304766.1
Coordinates 44988..45368 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag D0895_RS00235 Protein ID WP_025304767.1
Coordinates 45368..45589 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0895_RS00205 40235..41515 + 1281 WP_033645140.1 DUF3748 domain-containing protein -
D0895_RS00210 41546..41893 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
D0895_RS00215 42203..42616 + 414 WP_004933919.1 heat shock chaperone IbpA -
D0895_RS00220 42723..43151 + 429 WP_004933922.1 heat shock chaperone IbpB -
D0895_RS00225 43319..44977 + 1659 WP_187048490.1 putative transporter -
D0895_RS00230 44988..45368 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
D0895_RS00235 45368..45589 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
D0895_RS00240 45663..46913 - 1251 WP_047025992.1 valine--pyruvate transaminase -
D0895_RS00245 47927..48706 + 780 WP_033645137.1 2OG-Fe dioxygenase family protein -
D0895_RS00250 48786..49925 + 1140 WP_033645136.1 PLP-dependent aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T170173 WP_025304766.1 NZ_CP060276:c45368-44988 [Serratia ureilytica]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T170173 NZ_CP077094:c4961759-4961457 [Pseudomonas promysalinigenes]
ATGAAGAGTATCAAGCAGACAGCCACCTACAGGAATTGGGAGCGCAAGCTACGGGACAAGCAGGCTAGAGCAATTATTGC
TGCACGCGTTTTTCGTCTGGCGCATGGTTTGCTTGGTGATGTCCAGCCAGTGGGTCAAGGTATCAGCGAACTGCGTATCC
ATCATGGACCCGGTTACCGTATCTATTATCAGCAACGCGGTAATCAGTTGGTACTGTTGTTATGTGGTGGGGACAAGAGC
AGCCAGTCGCGAGATATCGAGACAGCGAAATCACTGGCCAGCCAGTGGAGTGATGATGAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT170173 WP_025304767.1 NZ_CP060276:c45589-45368 [Serratia ureilytica]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT170173 NZ_CP077094:c4961460-4961161 [Pseudomonas promysalinigenes]
ATGAAAGAACAGTTTTATGATTACGACCCAGCCGAAGCGCTGACCGATGCAGAGTCCATTGCCATATTCATGGAGGATGC
GTTTGAGACGGGTGACGCGGCGTACATTGCGCAGGCCCTCGGTGTAGTGGCCCGCGCTAAGGGTATGACCACTATTGCCA
CTGAGGCGGGTGTTTCCCGGGAGCATCTGTATCGGTCGTTCTCGGAGAAAGGTAACCCTACGCTCAAGACGATGTTGGCT
GTGATGCGGGCGGTTGGTCTGGACCTGACCTCCCGCAGACACAGCAAACCGGCGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References