Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 917841..918349 Replicon chromosome
Accession NZ_CP060271
Organism Staphylococcus xylosus strain DMSX03

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag DMSX03_RS04130 Protein ID WP_029377966.1
Coordinates 918149..918349 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag DMSX03_RS04125 Protein ID WP_069796648.1
Coordinates 917841..918134 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMSX03_RS04100 912952..913740 + 789 WP_186335562.1 hydroxyethylthiazole kinase -
DMSX03_RS04105 913743..914381 + 639 WP_081225106.1 thiamine phosphate synthase -
DMSX03_RS04110 914469..915356 + 888 WP_038678892.1 membrane protein insertase YidC -
DMSX03_RS04115 915454..916101 - 648 WP_081324837.1 HD domain-containing protein -
DMSX03_RS04120 916214..917698 - 1485 WP_069796650.1 cardiolipin synthase -
DMSX03_RS04125 917841..918134 + 294 WP_069796648.1 copper-sensing transcriptional repressor CsoR Antitoxin
DMSX03_RS04130 918149..918349 + 201 WP_029377966.1 heavy-metal-associated domain-containing protein Toxin
DMSX03_RS04135 918564..918704 + 141 WP_099265859.1 hypothetical protein -
DMSX03_RS04140 918993..920198 - 1206 WP_058625514.1 rod shape-determining protein RodA -
DMSX03_RS04145 920450..921520 + 1071 WP_038678888.1 D-alanine--D-alanine ligase -
DMSX03_RS04150 921533..922888 + 1356 WP_099265860.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-64)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7628.68 Da        Isoelectric Point: 4.3997

>T170165 WP_029377966.1 NZ_CP060271:918149-918349 [Staphylococcus xylosus]
VQSKVIYVSDINSERQYQIKQRLMNVIGVHNVAIDIDKGEILVDFETPASLNNLEKEIYDLGYQIF

Download         Length: 201 bp

>T170165 NZ_CP077093:128983-129255 [Pseudomonas vanderleydeniana]
ATGGCGTGGAGGATTGAATTCGAATCGTCGGCTGCCAAAGAGTTGGGCAAGCTCGATAAACAGACCGCACTACGAATTCT
GAAATTCCTGAGGGAGCGCCTTGCGGCACTGGAGGACCCTCGCAGTATCGGCGAAGCCCTCAAGGGCTCGAAGCTGGGTC
AGTTCTGGAAGTATCGGGTCGGGGATTACCGCATCATCGCCAACATACAGGACGAAGTCGTCAGTATCCTCATTGTTCGC
GTCGGCAATCGACGGGATGTCTACAAACACTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11123.79 Da        Isoelectric Point: 7.3236

>AT170165 WP_069796648.1 NZ_CP060271:917841-918134 [Staphylococcus xylosus]
VTEIQKAHHSDQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVGKGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT170165 NZ_CP077093:128775-128999 [Pseudomonas vanderleydeniana]
ATGCTCGCTATCCGTCTGCCTCAAGACATTGAAAATCGCTTGGAAGCCCTTGCTGCCGCGACTGGACGCACCAAGACATT
CTATGCCCGGCAAGCCATTCTCGAGCATATCGACAACCTCGAGGACATCTACCTGGCTGAACAGCGCCTGGCGGACGTCC
GCGCCGGTCGAAGCAAGACCATGACCCTGGAAGAGCTGGAACAACAGTATGGCGTGGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References