Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 264637..265249 Replicon chromosome
Accession NZ_CP060270
Organism Streptococcus pyogenes strain SP1384

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag H7X57_RS01435 Protein ID WP_010922665.1
Coordinates 264637..264972 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7X57_RS01440 Protein ID WP_002988079.1
Coordinates 264962..265249 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7X57_RS01400 (H7X57_01390) 260015..260533 + 519 WP_002982682.1 NYN domain-containing protein -
H7X57_RS01405 (H7X57_01395) 260630..261490 + 861 WP_002982687.1 DegV family protein -
H7X57_RS01410 (H7X57_01400) 261626..262132 + 507 WP_002988070.1 hypothetical protein -
H7X57_RS01415 (H7X57_01405) 262129..262335 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
H7X57_RS01420 (H7X57_01410) 262553..262999 + 447 WP_002982710.1 50S ribosomal protein L13 -
H7X57_RS01425 (H7X57_01415) 263020..263412 + 393 WP_002982716.1 30S ribosomal protein S9 -
H7X57_RS01430 263532..264539 - 1008 Protein_232 site-specific integrase -
H7X57_RS01435 (H7X57_01430) 264637..264972 - 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7X57_RS01440 (H7X57_01435) 264962..265249 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7X57_RS01445 (H7X57_01440) 265910..266683 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
H7X57_RS01450 (H7X57_01445) 267130..267558 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
H7X57_RS01455 (H7X57_01450) 267593..268108 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
H7X57_RS01460 (H7X57_01455) 268156..269085 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
H7X57_RS01465 (H7X57_01460) 269089..270072 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T170164 WP_010922665.1 NZ_CP060270:c264972-264637 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170164 NZ_CP077092:c5100769-5100365 [Pseudomonas iranensis]
ATGGAGCTGATCCACTTTCCATTTGAGCGAGTCATTGAAATAAACACACAGATCTTGACTACTGAGCCCGGCATGAAGGG
GCGTGTGAATATTCCCATCTTGCAAGGCGCGCTCGCCAGAATCGACAATGCGATAGCCTATAACGGGCTCGACGATGTAT
TTGAAATTGCTGCCAAATACACTGCCAGCATCGCGCAAGGCCACGCGTTGCCTGATGCCAACAAGCGCACCGGGCTGGCA
GTCGGCTTGGAATATCTCTCGCTCAATGATTATGAAATCACCTTGGACAACGATCTGCTGGCGGATGCCGTCAGGGATTT
GGTTACCGGTGAGATCAACGAACATGACTTCGCTGACATTCTTTACTCCTGCTTCAAGGCTTCTCAAAACCAGGGATCGT
ACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170164 WP_002988079.1 NZ_CP060270:c265249-264962 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170164 NZ_CP077092:c5100939-5100769 [Pseudomonas iranensis]
ATGAACCACAAGCTGAGCACCTATGGCGTATGCATAGTAGATAGGCCCAAAATCAAAGCCACCAAGAAGCTGGACTTGGG
AGGCGATCAGGGTAAGCAGATCGTTTACTCAGAAACGAAACTGGTTCTCAGAACTCACCAGAAGACCTTCAAGAAGCTGG
CTGACATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References