Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 258641..259253 Replicon chromosome
Accession NZ_CP060268
Organism Streptococcus pyogenes strain SP1426

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag H7X58_RS01370 Protein ID WP_010922665.1
Coordinates 258641..258976 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7X58_RS01375 Protein ID WP_002988079.1
Coordinates 258966..259253 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7X58_RS01335 (H7X58_01325) 254019..254537 + 519 WP_002982682.1 NYN domain-containing protein -
H7X58_RS01340 (H7X58_01330) 254634..255494 + 861 WP_002982687.1 DegV family protein -
H7X58_RS01345 (H7X58_01335) 255630..256136 + 507 WP_002988070.1 hypothetical protein -
H7X58_RS01350 (H7X58_01340) 256133..256339 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
H7X58_RS01355 (H7X58_01345) 256557..257003 + 447 WP_002982710.1 50S ribosomal protein L13 -
H7X58_RS01360 (H7X58_01350) 257024..257416 + 393 WP_002982716.1 30S ribosomal protein S9 -
H7X58_RS01365 257536..258543 - 1008 Protein_232 site-specific integrase -
H7X58_RS01370 (H7X58_01365) 258641..258976 - 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7X58_RS01375 (H7X58_01370) 258966..259253 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7X58_RS01380 (H7X58_01375) 259914..260687 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
H7X58_RS01385 (H7X58_01380) 261134..261562 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
H7X58_RS01390 (H7X58_01385) 261597..262112 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
H7X58_RS01395 (H7X58_01390) 262160..263089 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
H7X58_RS01400 (H7X58_01395) 263093..264076 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T170162 WP_010922665.1 NZ_CP060268:c258976-258641 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170162 NZ_CP077092:3643826-3644038 [Pseudomonas iranensis]
ATTGAGCAATTCAACCTTCGCGCTTCAGCATCGCTGCTTCGCAAAGTTGGAGCGGCTGCGCAGACGCTTTCTTCAGTTCC
ACATGGTTTTCGCTTCGGCCGGATACCGGGCACTCGCGAAATGGTGATTCATCCGAACTATCTGCTGGTCTATCGGGTGA
ATGGCCAGATCCGAATACTGACGGTAATTCATGCCCGAAAGAAATATCCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170162 WP_002988079.1 NZ_CP060268:c259253-258966 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170162 NZ_CP077092:3643585-3643779 [Pseudomonas iranensis]
ATGAGCGCTGAACTCTCACTTATTGTTTCAGACTTCGAAACCGAAGAAGAGGCTGCGAGCTATGACCTTTGGTATCGGGC
CAAAGTACAAGCTGCACTTGATGATCCGCGACCTGGAATCCCTCACGATGAGGCAATGGTGATTCTGGCCCAAAAGATAG
AAGAGAGACGCAAAAATCGACGCGCTGCCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References