170161

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 264639..265251 Replicon chromosome
Accession NZ_CP060267
Organism Streptococcus pyogenes strain SP1448

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag H7X59_RS01435 Protein ID WP_010922665.1
Coordinates 264639..264974 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7X59_RS01440 Protein ID WP_002988079.1
Coordinates 264964..265251 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7X59_RS01400 (H7X59_01390) 260017..260535 + 519 WP_002982682.1 NYN domain-containing protein -
H7X59_RS01405 (H7X59_01395) 260632..261492 + 861 WP_002982687.1 DegV family protein -
H7X59_RS01410 (H7X59_01400) 261628..262134 + 507 WP_002988070.1 hypothetical protein -
H7X59_RS01415 (H7X59_01405) 262131..262337 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
H7X59_RS01420 (H7X59_01410) 262555..263001 + 447 WP_002982710.1 50S ribosomal protein L13 -
H7X59_RS01425 (H7X59_01415) 263022..263414 + 393 WP_002982716.1 30S ribosomal protein S9 -
H7X59_RS01430 263534..264541 - 1008 Protein_232 site-specific integrase -
H7X59_RS01435 (H7X59_01430) 264639..264974 - 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7X59_RS01440 (H7X59_01435) 264964..265251 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7X59_RS01445 (H7X59_01440) 265912..266685 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
H7X59_RS01450 (H7X59_01445) 267132..267560 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
H7X59_RS01455 (H7X59_01450) 267595..268110 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
H7X59_RS01460 (H7X59_01455) 268158..269087 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
H7X59_RS01465 (H7X59_01460) 269091..270074 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T170161 WP_010922665.1 NZ_CP060267:c264974-264639 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170161 NZ_CP077092:2903223-2903504 [Pseudomonas iranensis]
ATGACCTATGAACTGGAATTTTCTGAAAAGGCTTGGAAGGAGTGGCGAAAGCTTGGGTCGGAGCTCAGAGAGCAGTTCAA
AAATAAACTTGTTGAAAGGCTGGCAAATCCCCACGTTCCGGCGGCTCGTCTGAAAGGATTGAGTAACGCCTATAAAATCA
AGCTTCGAAGCGCTGGATATCGGTTGGTCTATCGGGTCAGGGATGAGGTACTGGTCGTTACGGTGATAGCGGTCGGGAAA
CGGCAGGGTGGGGATGTCTACAGGCAGGCGCTAAAGCGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170161 WP_002988079.1 NZ_CP060267:c265251-264964 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170161 NZ_CP077092:2902985-2903233 [Pseudomonas iranensis]
ATGACGCACATTGTTCTTTCTCACGTCGTAGCGAGTATTTCCGAATTGAAAAAAAATCCTATGGGTACAGTGGCAGCTGG
TGGAGGCCGGTCTGTGGCGATCCTTAATCGAAACGAACCGGCCTTCTACTGTGTTCCTGCCAAGGAATATGAAGCAATGA
TGGAGCGCTTGGAGGATCTGGAACTGATCGCCCTTTGCAAAGAGCGAGAAAACGATCCGACCATCAAGGTATCCATTGAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References