Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1818584..1819137 Replicon chromosome
Accession NZ_CP060263
Organism Dickeya zeae strain JZL7

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag H7F34_RS08065 Protein ID WP_219953060.1
Coordinates 1818823..1819137 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag H7F34_RS08060 Protein ID WP_219953059.1
Coordinates 1818584..1818820 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F34_RS08025 1814349..1814605 - 257 Protein_1568 integrase core domain-containing protein -
H7F34_RS08030 1814602..1815003 + 402 Protein_1569 zincin-like metallopeptidase domain-containing protein -
H7F34_RS08035 1815133..1815369 + 237 WP_077246314.1 type II toxin-antitoxin system CcdA family antitoxin -
H7F34_RS08040 1815372..1815686 + 315 WP_219953056.1 CcdB family protein -
H7F34_RS22155 1815683..1815826 - 144 Protein_1572 mobilization protein mobC -
H7F34_RS08045 1815870..1816583 + 714 WP_219953057.1 hypothetical protein -
H7F34_RS08050 1816819..1817976 - 1158 WP_219953058.1 hypothetical protein -
H7F34_RS08055 1818114..1818299 - 186 Protein_1575 integrase -
H7F34_RS08060 1818584..1818820 + 237 WP_219953059.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H7F34_RS08065 1818823..1819137 + 315 WP_219953060.1 CcdB family protein Toxin
H7F34_RS08070 1819693..1820715 - 1023 WP_219951677.1 IS110 family transposase -
H7F34_RS08075 1820811..1821842 - 1032 WP_219953061.1 IS630 family transposase -
H7F34_RS08080 1821961..1822494 - 534 WP_219953062.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hcp / vgrG1 1815372..1860332 44960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11570.57 Da        Isoelectric Point: 8.8837

>T170144 WP_219953060.1 NZ_CP060263:1818823-1819137 [Dickeya zeae]
MQFTVYGNTGKSAIYPLLLDVTSDIIRQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRVQVKAAIDFLIDGI

Download         Length: 315 bp

>T170144 NZ_CP077091:1735411-1735719 [Pseudomonas hamedanensis]
ATGAGCCAGACTTTGACGAATTTCGACATGGTCGCGCTGCTGGACAGTGACGAAGCCATCAGCGAATACCTGTCTCAGGT
GCTAGCAGACGGAGACAGCGAAGAGTTCCTTCGCGCGATCGGTTACGTGCTCAGGGCCCGAGGCATGACGCAGATAGCCA
AAAACTCAGGCATGGGCCGCGAGAGTTTGTACAAAGCATTCGCTCCCGGAGCGAAGCCGAGATTTGACACAGTGTTGAAG
GTGATTCATGCGCTGGGCATCGATCTTTGTGCGCAGCCGGGGCATGGGATCAATCACTCCGTATCCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9108.17 Da        Isoelectric Point: 6.7184

>AT170144 WP_219953059.1 NZ_CP060263:1818584-1818820 [Dickeya zeae]
MTVKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRHHEAKKWQEENREAIDALNRFHDERSCFSDEYRTF

Download         Length: 237 bp

>AT170144 NZ_CP077091:1735115-1735408 [Pseudomonas hamedanensis]
ATGACTTATCTTATCCAGCAAACTGCAACCTTCCAGGCTTGGCACCGCTCGATCCGAGACCTGCGAGCCAAAGTGGCCAT
CGCGCGTCGTATTGATCGAGCCTCAACAGGTAATCTCGGCGACGCCAAATCGGTCGGTGATGGAGTTTCTGAGATGCGTC
TGGACGTAGGCGCGGGCTACCGAGTGTATTTCACCATCCGCAACGGTGCAGTAATTGTTCTGCTGGCCGGAGGCGATAAA
TCCTCACAAAGCGCAGACATCCGACGCGCACAAAAAATGGCAAAGGAGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References