170142

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1680788..1681405 Replicon chromosome
Accession NZ_CP060263
Organism Dickeya zeae strain JZL7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H7F34_RS07335 Protein ID WP_023639454.1
Coordinates 1681226..1681405 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H7F34_RS07330 Protein ID WP_219952965.1
Coordinates 1680788..1681198 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F34_RS07305 1676285..1677202 + 918 WP_219952962.1 iron-siderophore ABC transporter substrate-binding protein -
H7F34_RS07310 1677199..1678221 + 1023 WP_168362899.1 iron ABC transporter permease -
H7F34_RS07315 1678214..1679263 + 1050 WP_219952963.1 iron ABC transporter permease -
H7F34_RS07320 1679275..1680120 + 846 WP_219953430.1 ABC transporter ATP-binding protein -
H7F34_RS07325 1680117..1680740 + 624 WP_219952964.1 RraA family protein -
H7F34_RS07330 1680788..1681198 - 411 WP_219952965.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H7F34_RS07335 1681226..1681405 - 180 WP_023639454.1 type II toxin-antitoxin system HicA family toxin Toxin
H7F34_RS07340 1682083..1682742 + 660 WP_219952966.1 hypothetical protein -
H7F34_RS07345 1683149..1684216 - 1068 WP_219952967.1 MBL fold metallo-hydrolase -
H7F34_RS07350 1684380..1685306 - 927 WP_219952968.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6544.69 Da        Isoelectric Point: 10.7838

>T170142 WP_023639454.1 NZ_CP060263:c1681405-1681226 [Dickeya zeae]
MDSRTLMAEIKADGWELVRINGSHHHFIHPAKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T170142 NZ_CP077090:c5591577-5591233 [Pseudomonas zeae]
ATGCGAACCGTATTCTTTGAAACAACGATATTTACCACAAGCGTTGGTCAGTACCTGACAGACGATGAGTACCGAGAACT
GCAGGCTTATATGCAGGGCAATCCGTTGGCAGGCGATGTGATGCCCCGAACGGGTGGATTCAGAAAACTACGCTGGGCTG
ATGCTCGACGTGGCAAGGGCCGACGAGGCGGCTTGCGGGTCATCTATTATTGGCTTATGAATGATGGTCAGTTCTGGATG
TTTGCAATTTACGACAAAGATGAGCTTGAGAATCTGACTGCCGAGCAAGAAAAGGCGCTCAAAAAAGCCATAGATAAAGA
GTTGAAAACACGAGGTACCCCATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14499.58 Da        Isoelectric Point: 4.4227

>AT170142 WP_219952965.1 NZ_CP060263:c1681198-1680788 [Dickeya zeae]
MFYPIAIEAGDDAHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQAIPAVSSVGTLAKSPEYIGYTWAV
VDIDVTRLMGGVEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERMSSLR

Download         Length: 411 bp

>AT170142 NZ_CP077090:c5591236-5590922 [Pseudomonas zeae]
ATGAAAAAACGCGACCTGTTTGCAGAGTTGATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAAGGAAAAATTACCCT
GCGCAATACAGTGCTTGAGGACAAACCAGTCCCGGAAGTCGGAGCCCAAGAAATCGTGGCTTTGAGAGAAAAGTTACATA
TGTCTCAAGCCGTCTTTGCCAAGCGAATCAGGGCGAGTCCCAGCACTCTGAGAAACTGGGAGCAGGAAAAGTCAAAGCCA
AATGCTCAAGCTGCTTTGTTGATCCGTTTGGTTGAAAAATTCCCTGACATGGTTGACCGCCTGAGCGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References