Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1111986..1112611 Replicon chromosome
Accession NZ_CP060263
Organism Dickeya zeae strain JZL7

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag H7F34_RS05085 Protein ID WP_009114000.1
Coordinates 1111986..1112189 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2BUK3
Locus tag H7F34_RS05090 Protein ID WP_012883774.1
Coordinates 1112243..1112611 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F34_RS05055 1107608..1107946 + 339 WP_002208627.1 P-II family nitrogen regulator -
H7F34_RS05060 1107990..1109282 + 1293 WP_168363204.1 ammonium transporter AmtB -
H7F34_RS05065 1109406..1110269 - 864 WP_219952754.1 acyl-CoA thioesterase II -
H7F34_RS05070 1110487..1111068 + 582 WP_219952755.1 YbaY family lipoprotein -
H7F34_RS05075 1111109..1111435 - 327 WP_219952756.1 MGMT family protein -
H7F34_RS05085 1111986..1112189 - 204 WP_009114000.1 HHA domain-containing protein Toxin
H7F34_RS05090 1112243..1112611 - 369 WP_012883774.1 Hha toxicity modulator TomB Antitoxin
H7F34_RS05095 1113121..1113264 - 144 WP_012770724.1 type B 50S ribosomal protein L36 -
H7F34_RS05100 1113280..1113531 - 252 WP_168363201.1 type B 50S ribosomal protein L31 -
H7F34_RS05105 1113705..1116851 - 3147 WP_219952757.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T170140 WP_009114000.1 NZ_CP060263:c1112189-1111986 [Dickeya zeae]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T170140 NZ_CP077090:c2604638-2604288 [Pseudomonas zeae]
ATGGATGCTCTATTTATCGAATTGCCTGTATTTCAGAAGCACCGAGACGACTATCTGGATGACGATCTGTTTCGCAGCTT
TCAACTGGAGCTGCTGAAAAATCCGGAAGCGGGCGATCTCATCGAGGACACAGGCGGGCTTCGTAAAATTCGCTTTGGCG
ACCAACGAAGAGGGAAAGGTAAGCGCAGCGGATTACGAGTGATTTATTACTGGTGGTCAGGCTTCGATCAGTTCTGGCTC
TTTACCGTCTACAACAAAAACGAGCAGGACGATTTGACGCCTGCCCAGAAAAAACTTTTCAGAAAAACGCTGGATAGAGA
ACTCAACGCGAGAACCCACTATGAAACGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14186.04 Da        Isoelectric Point: 5.1811

>AT170140 WP_012883774.1 NZ_CP060263:c1112611-1112243 [Dickeya zeae]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSVCTVVKT

Download         Length: 369 bp

>AT170140 NZ_CP077090:c2604298-2603984 [Pseudomonas zeae]
ATGAAACGTGACATTTTTTCCGAACTGATGGATGGACTGGAAGCACTGGCCGATGAACGCCAAGGCAAAATCACCTTGCG
TACCCACAAAGTTCAACTGCCAAAACTGATGCCGATCACTGCTGAAGAAGTGATAGCCATCCGTCAGCAACTTAATCTTT
CCCGGTCAGTATTCGCGATGTATCTACGCACCAACACGCGAACGCTCGAAAACTGGGAGCAAGGACGAGCAACGCCCAAT
GCTCAGGCCACAACCCTGATCCGTCTGGTCGAGCGTTTTCCACAGACAATCGAACAACTCGCAGCCCTGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QCC2

References