Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 298514..299162 Replicon chromosome
Accession NZ_CP060259
Organism Stenotrophomonas maltophilia strain JZL8

Toxin (Protein)


Gene name PumA Uniprot ID A0A0L8AET4
Locus tag H7F32_RS01320 Protein ID WP_010486984.1
Coordinates 298514..298801 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0L8AF77
Locus tag H7F32_RS01325 Protein ID WP_029380112.1
Coordinates 298860..299162 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F32_RS01290 293780..294748 + 969 WP_049454336.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
H7F32_RS01295 294745..295476 + 732 WP_224328872.1 type III pantothenate kinase -
H7F32_RS01300 295486..296334 + 849 WP_224328873.1 SPOR domain-containing protein -
H7F32_RS01310 296535..297659 - 1125 WP_082587902.1 hypothetical protein -
H7F32_RS01315 297682..298281 - 600 WP_139042439.1 hypothetical protein -
H7F32_RS01320 298514..298801 + 288 WP_010486984.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7F32_RS01325 298860..299162 + 303 WP_029380112.1 putative addiction module antidote protein Antitoxin
H7F32_RS01330 299220..299543 - 324 WP_010486982.1 hypothetical protein -
H7F32_RS01335 299624..300031 - 408 WP_010486980.1 hypothetical protein -
H7F32_RS01340 300614..301384 + 771 WP_224328874.1 DUF3011 domain-containing protein -
H7F32_RS01345 301409..301756 - 348 WP_224328875.1 hypothetical protein -
H7F32_RS01350 301887..302807 + 921 WP_010486976.1 arginase -
H7F32_RS01355 302970..303107 + 138 WP_014035659.1 entericidin A/B family lipoprotein -
H7F32_RS01360 303310..303531 + 222 WP_004137109.1 CsbD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 287836..306814 18978


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10744.34 Da        Isoelectric Point: 10.8940

>T170137 WP_010486984.1 NZ_CP060259:298514-298801 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAREIARAL

Download         Length: 288 bp

>T170137 NZ_CP077090:c1825170-1824886 [Pseudomonas zeae]
ATGCGAGTTGAGTGGCTAAAAACTGCGTTAAAAAATCTCGATGATGAAGCTGCCTACATCGCTCTCGATAATCCGAAGGC
TGCTTCAGAATTTGTCCAGGCTATTTTCGCCAACGTTGATCACCTCACTCGATTTCCCTCTTCGGGTCGCGAAGGCCGCC
TTCCGGGCACTCGGGAGTGGGTCGTTCCTGATCGGCCCTATTTGATTCCTTATCGCGTCCGTCAAAGCCGATTGCAGGTT
TTGCGTATTTTCCATACCCGACGGCTCCCACCCAAGGCGTGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10750.33 Da        Isoelectric Point: 8.0359

>AT170137 WP_029380112.1 NZ_CP060259:298860-299162 [Stenotrophomonas maltophilia]
MAIKRKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAA

Download         Length: 303 bp

>AT170137 NZ_CP077090:c1825399-1825160 [Pseudomonas zeae]
ATGTCCGTCATGTCCCTGCGTATCCCAGACGAAATTGCCGACACGCTCGCCAACCTCGCCAAAGCAACCGGTCGCACCAA
GTCTTACTTGGCGGTGGATGCATTGCGTGAATACCTCGCACGCGAAGCCTGGCAAATCGAAGAAATTCAGAAAGCACTGA
AAGAAGCCGACGCTGGTGATTTCGCTACTGATGAGGAAGTCAGGGCCATCGCGGAAAAATGGAATGCCAATGCGAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L8AET4

Antitoxin

Source ID Structure
AlphaFold DB A0A0L8AF77

References