Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2308271..2308833 Replicon chromosome
Accession NZ_CP060244
Organism Entomobacter blattae strain G55GP

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JGUZn3_RS10370 Protein ID WP_203413438.1
Coordinates 2308507..2308833 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JGUZn3_RS10365 Protein ID WP_203413437.1
Coordinates 2308271..2308513 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGUZn3_RS10315 2304273..2304443 - 171 WP_203413427.1 hypothetical protein -
JGUZn3_RS10320 2304452..2304766 - 315 WP_203413428.1 DUF3383 family protein -
JGUZn3_RS10325 2304717..2305379 - 663 WP_203413429.1 hypothetical protein -
JGUZn3_RS10330 2305363..2305791 - 429 WP_203413430.1 hypothetical protein -
JGUZn3_RS10335 2305857..2306141 + 285 WP_203413431.1 type II toxin-antitoxin system RelE/ParE family toxin -
JGUZn3_RS10340 2306131..2306457 + 327 WP_203413432.1 HigA family addiction module antidote protein -
JGUZn3_RS10345 2306459..2307013 - 555 WP_203413433.1 hypothetical protein -
JGUZn3_RS10350 2307107..2307388 + 282 WP_203413434.1 type II toxin-antitoxin system RelE/ParE family toxin -
JGUZn3_RS10355 2307399..2307731 + 333 WP_203413435.1 HigA family addiction module antidote protein -
JGUZn3_RS10360 2307764..2308198 - 435 WP_203413436.1 DUF4054 domain-containing protein -
JGUZn3_RS10365 2308271..2308513 + 243 WP_203413437.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JGUZn3_RS10370 2308507..2308833 + 327 WP_203413438.1 endoribonuclease MazF Toxin
JGUZn3_RS10375 2308852..2309073 - 222 WP_203413439.1 hypothetical protein -
JGUZn3_RS10380 2309070..2309402 - 333 WP_203413440.1 hypothetical protein -
JGUZn3_RS10385 2309404..2310450 - 1047 WP_203413441.1 DUF2184 domain-containing protein -
JGUZn3_RS10390 2310465..2310983 - 519 WP_203413442.1 hypothetical protein -
JGUZn3_RS10395 2310983..2312530 - 1548 WP_203413443.1 DUF2213 domain-containing protein -
JGUZn3_RS10400 2312720..2313325 + 606 WP_203414912.1 PD-(D/E)XK nuclease-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2306459..2355532 49073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12410.51 Da        Isoelectric Point: 9.7896

>T170135 WP_203413438.1 NZ_CP060244:2308507-2308833 [Entomobacter blattae]
MVKSYIPECGDIIWISFDPSKGHEQQKRRPALVLSPKRYNQKTNLLLCCPITSRIKGYPFEVLLDKQNAILADQVKSFDW
KARNAEFKAKAPMNSIDETKEKLLTLLS

Download         Length: 327 bp

>T170135 NZ_CP077089:c1765885-1765706 [Pseudomonas tensinigenes]
GTGAATAGCCGTTTTTTAATCGGCCAACTCGTCGCAGACGGTTGGTATCTGGTACGGATCAAAGGAAGTCACCATCACTT
CAAGCATCCGACCAAACTAGGACTGGTCACCGTGCCACATCCGAAAAAGGATCTGCTGAAGAAAACGGCCATCAGTATTT
TGCAGCAGGCGCTGCTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8956.20 Da        Isoelectric Point: 5.0916

>AT170135 WP_203413437.1 NZ_CP060244:2308271-2308513 [Entomobacter blattae]
METSIKKWGNSTAIRIPSALIKESGMKIDQAVDVQVKDDTIIIKPIKKQKYALDSLLSGITEDNRHNEVESFGPVGNEEW

Download         Length: 243 bp

>AT170135 NZ_CP077089:c1765669-1765262 [Pseudomonas tensinigenes]
ATGCTCTACCCGATTGCGATTTCAATTGGCGATGACCAACACGCCTGGGGTGTAGAAGTCCCGGACATTCCTGGATGCTT
TTCCGCCGGAGAGGATCTGGACGATGCCGTCGCCATGGCCCGCGAAGCCATCGAAGGTCATTTCGAGATTCTCGCGGACG
ACGACGCCCCCATTCCAGCGGCCAGCAAACTGAGCCTGCACGTAGCCAACCCGAAATACGCCGGTTGTGCATGGGCCGTG
GTGGATATCGATGTGCTCAAGTACTTGGGCAAAGCCCAAAAGCTCAACATCACCCTGCCGGGGCACTTGCTCAACCGCAT
TGACGAGTATGTGTTGCATCACCCGGAAGAGAAAAGCCGCTCGGGCTTTCTGGCGTCGGCGGCTCTGAAAGTTTTGCAGC
AGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References