Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2243407..2243996 Replicon chromosome
Accession NZ_CP060244
Organism Entomobacter blattae strain G55GP

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JGUZn3_RS10020 Protein ID WP_203413372.1
Coordinates 2243407..2243661 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JGUZn3_RS10025 Protein ID WP_203413373.1
Coordinates 2243658..2243996 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGUZn3_RS09985 2239334..2239705 - 372 WP_203413365.1 hypothetical protein -
JGUZn3_RS09990 2240009..2240677 - 669 WP_203413366.1 hypothetical protein -
JGUZn3_RS09995 2240740..2240967 + 228 WP_203413367.1 AbrB family transcriptional regulator -
JGUZn3_RS10000 2240964..2241380 + 417 WP_203413368.1 type II toxin-antitoxin system death-on-curing family toxin -
JGUZn3_RS10005 2241377..2242381 - 1005 WP_203413369.1 hypothetical protein -
JGUZn3_RS10010 2242374..2242688 - 315 WP_203413370.1 hypothetical protein -
JGUZn3_RS10015 2242690..2243331 - 642 WP_203413371.1 hypothetical protein -
JGUZn3_RS10020 2243407..2243661 + 255 WP_203413372.1 type II toxin-antitoxin system HicA family toxin Toxin
JGUZn3_RS10025 2243658..2243996 + 339 WP_203413373.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JGUZn3_RS10030 2243993..2246278 - 2286 WP_203413374.1 hypothetical protein -
JGUZn3_RS10035 2246403..2246666 + 264 WP_203413375.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
JGUZn3_RS10040 2246653..2246934 + 282 WP_203413376.1 type II toxin-antitoxin system YafQ family toxin -
JGUZn3_RS10045 2247052..2247894 + 843 WP_203413377.1 YqaJ viral recombinase family protein -
JGUZn3_RS10050 2247891..2248871 + 981 WP_203413378.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2230845..2258273 27428


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(56-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9409.81 Da        Isoelectric Point: 11.0200

>T170132 WP_203413372.1 NZ_CP060244:2243407-2243661 [Entomobacter blattae]
MKAKHHRTLERVFKRPASGNIAWADIESLFMALGGEISERAGSRIGVFLFNEVRVFHRPHPSPKTDKGAVASVRKWLEDN
GVTP

Download         Length: 255 bp

>T170132 NZ_CP077089:514162-514344 [Pseudomonas tensinigenes]
ATGCGCAGTCGGGAAATGATCAGGATGATCGAAGACGATGGTTGGTATCTCGTGGCGGTGAAAGGCAGCCACCACCAATA
CAAGCATCCGCACAAGCCAGGAAGGGTGACGATCAAGCACCCTGATTCGGATCTGCCCAAGGGCACGATCAACAGCATTT
TGAAACAGGCGGGCTTGAAATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12359.17 Da        Isoelectric Point: 5.7302

>AT170132 WP_203413373.1 NZ_CP060244:2243658-2243996 [Entomobacter blattae]
MKNMMDINGYRAVIAFDPDINMFRGEFMELNGGADFYADTVEGLRKEGELSLKEFLALCKEKGIPPTKSYSGKLQVRFPE
RIHAAASTLASAQGISLNEFIVQAVTEATHKA

Download         Length: 339 bp

>AT170132 NZ_CP077089:514404-514805 [Pseudomonas tensinigenes]
ATGAAATTCCCGGTCGTTCTGCACAAGGATGCCGACTCAGACTACGGAGTGATCATCCCGGATGTCCCGGGTTGTTTCTC
CGCAGGCACCACGGTCGCTGAGGCGTTTGAAAATACTCAGGAGGCATTGGCGCTTCACTATGAGGGGTTGGTCGCCGACA
GCGCGCCGTTACCGCAAGTGCGGGACATTGATGTTCATCTCGATAACCCGGATTACGCGGGAGGGATCTGGGGCGTGGTC
GATTTTGATATCACCCCGTATTTCGGCAAGTCAGTGCGTTTTAACGCCACGCTGCCGGAGCAGTTGCTTGAGCGTATTGA
CCAGACAGTCCGCCGTGACCAGCGCTATCGATCCCGTTCCGGATTTCTCGCGGCGGCCGCCTTGCGCGAACTGTCGGTAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References