Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1422135..1422616 Replicon chromosome
Accession NZ_CP060244
Organism Entomobacter blattae strain G55GP

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag JGUZn3_RS06305 Protein ID WP_203414739.1
Coordinates 1422135..1422389 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag JGUZn3_RS06310 Protein ID WP_203412742.1
Coordinates 1422395..1422616 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGUZn3_RS06275 1418570..1418917 - 348 WP_203412736.1 VirB3 family type IV secretion system protein -
JGUZn3_RS06280 1418929..1419261 - 333 WP_203412737.1 TrbC/VirB2 family protein -
JGUZn3_RS06285 1419245..1419574 - 330 WP_203412738.1 hypothetical protein -
JGUZn3_RS06290 1419567..1420400 - 834 WP_203412739.1 lytic transglycosylase domain-containing protein -
JGUZn3_RS06295 1420514..1420840 + 327 WP_203412740.1 hypothetical protein -
JGUZn3_RS06300 1420991..1422061 + 1071 WP_203412741.1 hypothetical protein -
JGUZn3_RS06305 1422135..1422389 - 255 WP_203414739.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JGUZn3_RS06310 1422395..1422616 - 222 WP_203412742.1 ribbon-helix-helix protein, CopG family Antitoxin
JGUZn3_RS06315 1423893..1425101 + 1209 WP_203412743.1 Gfo/Idh/MocA family oxidoreductase -
JGUZn3_RS06320 1425143..1425304 + 162 WP_203412744.1 hypothetical protein -
JGUZn3_RS06325 1426011..1427372 - 1362 WP_203414841.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1358594..1422616 64022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9897.64 Da        Isoelectric Point: 10.3997

>T170131 WP_203414739.1 NZ_CP060244:c1422389-1422135 [Entomobacter blattae]
IMWEIRFSETASKEFSKLDKPVAKRLMNFLEERVVTLEDPRNLGKALRGHLGELWSYRVGDFRIIADIQDKKLCILILKT
GHRR

Download         Length: 255 bp

>T170131 NZ_CP077087:4200724-4201074 [Pseudomonas monsensis]
ATGGATGCTCTATTTATCGAATTGCCTGTGTTTCAGAAGCACCGAGACGACTATCTGGATGACGATCTGTTTCGCAGCTT
GCAACTGGAGTTGCTGAAAAATCCGGAAGCGGGCGATCTCATCGAGGACACAGGCGGGCTTCGTAAAATTCGCTTTAGCG
ACCAACGAAGAGGGAAAGGTAAACGTAGCGGATTACGAGTGATTTATTACTGGTGGTCAGGCTTCGATCAGTTCTGGCTC
TTTACCGTCTACAGCAAAAACGAGCAGGACGATTTGACGCCTGCCCAGAAAAAACTTTTCAGAAAGACACTGGATAAAGA
ACTCAACGCGAGAACCCACTATGAAACGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8454.64 Da        Isoelectric Point: 5.1088

>AT170131 WP_203412742.1 NZ_CP060244:c1422616-1422395 [Entomobacter blattae]
MTTTVRLNQNIEERLDFLAKQTGRTKTYYIAQLIENGLDELEDYYLAADVLEKIRKGKEKTISSSDLKKTLDL

Download         Length: 222 bp

>AT170131 NZ_CP077087:4201064-4201378 [Pseudomonas monsensis]
ATGAAACGTGACATTTTTTCCGAACTGATGGATGGACTGGAAGCACTGGCCGATGAACGCCAAGGCAAAATCACCTTGCG
TACCCACAAGGTTCAGTTGCCAAAACTGATGCCGATCACTGCGGATGAAGTCGTCGCCATCCGTCAGCAACTGAATCTGT
CCCGGTCAGTATTCGCAATGTATCTGCGCACCAACACGCGAACGCTGGAAAACTGGGAACAAGGACGAGCGACACCCAAT
GCTCAGGCCACCACCCTGATCCGTCTGGTCGAACGTTTCCCACAAACGATCGAACAACTCGCAGCCCTGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References