Detailed information of TA system TA170131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1422135..1422616
• Replicon: chromosome
• Accession: NZ_CP060244
• Organism: Entomobacter blattae strain G55GP

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: JGUZn3_RS06305
• Protein ID: WP_203414739.1
• Coordinates: 1422135..1422389 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: JGUZn3_RS06310
• Protein ID: WP_203412742.1
• Coordinates: 1422395..1422616 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGUZn3_RS06275	1418570..1418917	-	348	WP_203412736.1	VirB3 family type IV secretion system protein	-
JGUZn3_RS06280	1418929..1419261	-	333	WP_203412737.1	TrbC/VirB2 family protein	-
JGUZn3_RS06285	1419245..1419574	-	330	WP_203412738.1	hypothetical protein	-
JGUZn3_RS06290	1419567..1420400	-	834	WP_203412739.1	lytic transglycosylase domain-containing protein	-
JGUZn3_RS06295	1420514..1420840	+	327	WP_203412740.1	hypothetical protein	-
JGUZn3_RS06300	1420991..1422061	+	1071	WP_203412741.1	hypothetical protein	-
JGUZn3_RS06305	1422135..1422389	-	255	WP_203414739.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JGUZn3_RS06310	1422395..1422616	-	222	WP_203412742.1	ribbon-helix-helix protein, CopG family	Antitoxin
JGUZn3_RS06315	1423893..1425101	+	1209	WP_203412743.1	Gfo/Idh/MocA family oxidoreductase	-
JGUZn3_RS06320	1425143..1425304	+	162	WP_203412744.1	hypothetical protein	-
JGUZn3_RS06325	1426011..1427372	-	1362	WP_203414841.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1358594..1422616	64022

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9897.64 Da
• Isoelectric Point: 10.3997

>T170131 WP_203414739.1 NZ_CP060244:c1422389-1422135 [Entomobacter blattae]
IMWEIRFSETASKEFSKLDKPVAKRLMNFLEERVVTLEDPRNLGKALRGHLGELWSYRVGDFRIIADIQDKKLCILILKT
GHRR

Nucleotide

• Length: 255 bp

>T170131 NZ_CP077087:4200724-4201074 [Pseudomonas monsensis]
ATGGATGCTCTATTTATCGAATTGCCTGTGTTTCAGAAGCACCGAGACGACTATCTGGATGACGATCTGTTTCGCAGCTT
GCAACTGGAGTTGCTGAAAAATCCGGAAGCGGGCGATCTCATCGAGGACACAGGCGGGCTTCGTAAAATTCGCTTTAGCG
ACCAACGAAGAGGGAAAGGTAAACGTAGCGGATTACGAGTGATTTATTACTGGTGGTCAGGCTTCGATCAGTTCTGGCTC
TTTACCGTCTACAGCAAAAACGAGCAGGACGATTTGACGCCTGCCCAGAAAAAACTTTTCAGAAAGACACTGGATAAAGA
ACTCAACGCGAGAACCCACTATGAAACGTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8454.64 Da
• Isoelectric Point: 5.1088

>AT170131 WP_203412742.1 NZ_CP060244:c1422616-1422395 [Entomobacter blattae]
MTTTVRLNQNIEERLDFLAKQTGRTKTYYIAQLIENGLDELEDYYLAADVLEKIRKGKEKTISSSDLKKTLDL

Nucleotide

• Length: 222 bp

>AT170131 NZ_CP077087:4201064-4201378 [Pseudomonas monsensis]
ATGAAACGTGACATTTTTTCCGAACTGATGGATGGACTGGAAGCACTGGCCGATGAACGCCAAGGCAAAATCACCTTGCG
TACCCACAAGGTTCAGTTGCCAAAACTGATGCCGATCACTGCGGATGAAGTCGTCGCCATCCGTCAGCAACTGAATCTGT
CCCGGTCAGTATTCGCAATGTATCTGCGCACCAACACGCGAACGCTGGAAAACTGGGAACAAGGACGAGCGACACCCAAT
GCTCAGGCCACCACCCTGATCCGTCTGGTCGAACGTTTCCCACAAACGATCGAACAACTCGCAGCCCTGACCTGA